標題: Incidence of retinal vein occlusion with longterm exposure to ambient air pollution
作者: Zhang, Han-Wei
Lin, Chao-Wen
Kok, Victor C.
Tseng, Chun-Hung
Lin, Yuan-Pei
Li, Tsai-Chung
Sung, Fung-Chang
Wen, Chi Pang
Hsiung, Chao A.
Hsu, Chung Y.
電控工程研究所
Institute of Electrical and Control Engineering
公開日期: 24-九月-2019
摘要: This study aimed to investigate whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increases the risk of developing retinal vein occlusion (RVO) among the population of Taiwan. A retrospective cohort study involving 855,297 people was conducted. Cox proportional hazards regression analysis fitted the multiple pollutant models for two targeted pollutants, including total hydrocarbons (THC), nonmethane hydrocarbons (NMHC) were used, and the risk of RVO was estimated. The chi-squared test and one-way analysis of variance were used to test differences in demographics and comorbidity distribution among tertiles of the targeted pollutants. Before controlling for multiple pollutants, hazard ratios for the overall population were 19.88 (95% CI: 17.56-22.50) at 0.51-ppm increases in THC and 4.33 (95% CI: 3.97-4.73) at 0.27-ppm increases in NMHC. The highest adjusted hazard ratios for different multiple pollutant models of each targeted pollutant were statistically significant (all p values were.0.05) for all patients at 29.67 (95% CI: 25.57-34.42) for THC and 16.24 (95% CI: 14.14-18.65) for NMHC. Our findings suggest that long-term exposure to THC and NMHC contribute to RVO development.
URI: http://dx.doi.org/10.1371/journal.pone.0222895
http://hdl.handle.net/11536/154350
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0222895
期刊: PLOS ONE
Volume: 14
Issue: 9
起始頁: 0
結束頁: 0
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