標題: Long-term ambient hydrocarbons exposure and incidence of ischemic stroke
作者: Zhang, Han-Wei
Kok, Victor C.
Chuang, Shu-Chun
Tseng, Chun-Hung
Lin, Chin-Teng
Li, Tsai-Chung
Sung, Fung-Chang
Wen, Chi Pang
Hsiung, Chao A.
Hsu, Chung Y.
電控工程研究所
腦科學研究中心
Institute of Electrical and Control Engineering
Brain Research Center
公開日期: 4-十二月-2019
摘要: Exposure to air pollutants is known to have adverse effects on human health; however, little is known about the association between hydrocarbons in air and an ischemic stroke (IS) event. We investigated whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increased IS risk. This retrospective cohort study included 283,666 people aged 40 years or older in Taiwan. Cox proportional hazards regression analysis was used to fit single- and multiple-pollutant models for two targeted pollutants, total hydrocarbons (THC) and nonmethane hydrocarbons (NMHC), and estimated the risk of IS. Before controlling for multiple pollutants, hazard ratios (HRs) of IS with 95% confidence intervals for the overall population were 2.69 (2.64-2.74) at 0.16-ppm increase in THC and 1.62 (1.59-1.66) at 0.11-ppm increase in NMHC. For the multiple-pollutant models controlling for PM2.5, the adjusted HR was 3.64 (3.56-3.72) for THC and 2.21 (2.16-2.26) for NMHC. Our findings suggest that long-term exposure to THC and NMHC may be a risk factor for IS development.
URI: http://dx.doi.org/10.1371/journal.pone.0225363
http://hdl.handle.net/11536/154512
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0225363
期刊: PLOS ONE
Volume: 14
Issue: 12
起始頁: 0
結束頁: 0
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