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dc.contributor.authorChiu, Cheng-Hsinen_US
dc.contributor.authorJheng, Ting-Cianen_US
dc.contributor.authorPeng, Bo-Chunen_US
dc.contributor.authorChung, Wen-Shengen_US
dc.contributor.authorMong, Kwok-kong Tonyen_US
dc.date.accessioned2020-07-01T05:22:06Z-
dc.date.available2020-07-01T05:22:06Z-
dc.date.issued1970-01-01en_US
dc.identifier.issn1434-193Xen_US
dc.identifier.urihttp://dx.doi.org/10.1002/ejoc.202000439en_US
dc.identifier.urihttp://hdl.handle.net/11536/154516-
dc.description.abstractPolyhydroxamate desferrioxamines (DFO) are nontoxic siderophores endowed with high potential for development of therapeutic chelating agents. Herein, we report a modular and convergent strategy for diverse synthesis of macrocyclic and linear DFOs. The strategy employed orthogonally protected N-hydroxy-N-succinylcadaverine building blocks, which allowed bidirectional extension of the DFO structure. The efficiency of the new strategy was demonstrated by the total synthesis of 44-membered macrocyclic DFO-T-1, as well as four related DFO compounds in 11-13 linear steps and 2.1 %-10 % overall yields. Comparison of the iron binding affinity of the DFOs revealed DFO-E as the best chelator.en_US
dc.language.isoen_USen_US
dc.subjectSiderophoresen_US
dc.subjectDesferrioxaminesen_US
dc.subjectHydroxamateen_US
dc.subjectConvergent synthesisen_US
dc.subjectIron bindingen_US
dc.titleConvergent Synthesis of Macrocyclic and Linear Desferrioxaminesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/ejoc.202000439en_US
dc.identifier.journalEUROPEAN JOURNAL OF ORGANIC CHEMISTRYen_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000538567700001en_US
dc.citation.woscount0en_US
Appears in Collections:Articles