標題: Visceral obesity and cell cycle pathways serve as links in the association between bisphenol A exposure and breast cancer
作者: Wang, Tsu-Nai
Yang, Pei-Jing
Tseng, Yu-Ting
Tsai, Yi-Shan
Kuo, Po-Lin
Chiu, Chien-Chih
Liang, Shih-Shin
Hsieh, Tsung-Hua
Hou, Ming-Feng
Tsai, Eing-Mei
生物科技學系
Department of Biological Science and Technology
關鍵字: pathway;bisphenol A;breast cancer;gene sets;microarray
公開日期: 1-七月-2020
摘要: It has been identified that bisphenol A (BPA) exposure causes developmental toxicity in breast cells. However, the exact molecular mechanisms underlying the association between exposure to BPA and breast cancer remain unclear. The aim of the present study was to investigate the BPA-regulated signaling pathways associated with the aggressiveness and the development of breast cancer. Microarray technology and functional gene set analyses were used to evaluate BPA and breast cancer-associated biomarkers and pathways in a discovery-driven manner. Using individual dataset analyses, it was indicated that two BPA-associated gene sets, the visceral obesity pathway, involved in visceral fat deposits and the metabolic syndrome, and the cell cycle pathway, involved in cyclins and cell cycle regulation, were significantly associated with a high grade of aggressiveness and the development of estrogen receptor (ER)-positive breast cancer (between P<0.05 and 0.0001). The pooled analysis indicated that the most significant pathway was G(1)/S checkpoint regulation, and the cyclin and cell cycle regulation pathway for BPA-associated ER-positive cancer. Cancer cell signaling pathways were associated with healthy breast cells developing into breast cancer. The visceral obesity and the cell cycle pathways were indicated to link BPA exposure to breast cancer. The results of the present study demonstrate a significant association between breast cancer and BPA-regulated gene pathways.
URI: http://dx.doi.org/10.3892/ol.2020.11553
http://hdl.handle.net/11536/154837
ISSN: 1792-1074
DOI: 10.3892/ol.2020.11553
期刊: ONCOLOGY LETTERS
Volume: 20
Issue: 1
起始頁: 33
結束頁: 42
顯示於類別:期刊論文