完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang, Chung-Feng | en_US |
dc.contributor.author | Dai, Chia-Yen | en_US |
dc.contributor.author | Yeh, Ming-Lun | en_US |
dc.contributor.author | Huang, Ching-, I | en_US |
dc.contributor.author | Lee, Hsiang-Chun | en_US |
dc.contributor.author | Lai, Wen-Ter | en_US |
dc.contributor.author | Liang, Po-Cheng | en_US |
dc.contributor.author | Lin, Yi-Hung | en_US |
dc.contributor.author | Hsieh, Ming-Yen | en_US |
dc.contributor.author | Hou, Nai-Jen | en_US |
dc.contributor.author | Lin, Zu-Yau | en_US |
dc.contributor.author | Chen, Shinn-Cherng | en_US |
dc.contributor.author | Huang, Jee-Fu | en_US |
dc.contributor.author | Chuang, Wan-Long | en_US |
dc.contributor.author | Yu, Ming-Lung | en_US |
dc.date.accessioned | 2020-10-05T01:59:45Z | - |
dc.date.available | 2020-10-05T01:59:45Z | - |
dc.date.issued | 1970-01-01 | en_US |
dc.identifier.issn | 1607-551X | en_US |
dc.identifier.uri | http://dx.doi.org/10.1002/kjm2.12275 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/154877 | - |
dc.description.abstract | Hepatitis C virus (HCV) eradication deteriorates lipid profiles. Although HCV eradication may reduce the risk of vascular events as a whole, whether deteriorated lipid profiles increases the risk of cardio-cerebral disease in certain patients is elusive. Serial lipid profiles were measured before, during, at and 3 months after the end of direct-acting antivirals (DAAs) therapy, and annually thereafter in chronic hepatitis C patients who achieved a sustained virological response (SVR, undetectable HCV RNA at posttreatment week 12). The primary end-point was the occurrence of the events. A total of 617 patients were included, with a mean follow-up period of 26.8 months (range: 1-65 months). The total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels increased significantly from treatment week 4 to 2 years after treatment. Logistic regression analysis revealed that the factors independently associated with a significant cholesterol increase included age (odds ratio [OR]/95% confidence intervals [CIs]:1.02/1.006-1.039,P= .007) and smoking (OR/CI:3.21/1.14-9.02,P= .027). Five patients developed cardio-cerebral diseases during 1376 person-years follow-up period. Compared to patients without vascular events, a significantly higher proportion of those with vascular events experienced an LDL-C surge >40% (80% vs 19.9%,P= .001). Cox-regression analysis revealed that an LDL-C surge >40% was the only factor predictive of vascular events (HR/CI: 15.44/1.73-138.20,P= .014). Dyslipidemia occurred after HCV eradication, and it was associated with the risk of cardio-cerebrovascular diseases. Attention should also be paid to the extrahepatic consequence beyond liver-related complications in the post-SVR era. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | CAD | en_US |
dc.subject | DAA | en_US |
dc.subject | HCV | en_US |
dc.subject | lipid | en_US |
dc.subject | SVR | en_US |
dc.title | Cure or curd: Modification of lipid profiles and cardio-cerebrovascular events after hepatitis C virus eradication | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1002/kjm2.12275 | en_US |
dc.identifier.journal | KAOHSIUNG JOURNAL OF MEDICAL SCIENCES | en_US |
dc.citation.spage | 0 | en_US |
dc.citation.epage | 0 | en_US |
dc.contributor.department | 生物科技學院 | zh_TW |
dc.contributor.department | College of Biological Science and Technology | en_US |
dc.identifier.wosnumber | WOS:000548007000001 | en_US |
dc.citation.woscount | 0 | en_US |
顯示於類別: | 期刊論文 |