標題: A panel of eight microRNAs is a good predictive parameter for triple-negative breast cancer relapse
作者: Hong, Hsiao-Chin
Chuang, Cheng-Hsun
Huang, Wei-Chih
Weng, Shun-Long
Chen, Chia-Hung
Chang, Kuang-Hsin
Liao, Kuang-Wen
Huang, Hsien-Da
交大名義發表
生物科技學系
生物資訊及系統生物研究所
分子醫學與生物工程研究所
National Chiao Tung University
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
Institute of Molecular Medicine and Bioengineering
關鍵字: triple-negative breast cancer;miRNA signature;relapse;prediction;prognosis
公開日期: 1-一月-2020
摘要: Rationale: Triple-negative breast cancer (TNBC), which has the highest recurrence rate and shortest survival time of all breast cancers, is in urgent need of a risk assessment method to determine an accurate treatment course. Recently, miRNA expression patterns have been identified as potential biomarkers for diagnosis, prognosis, and personalized therapy. Here, we investigate a combination of candidate miRNAs as a clinically applicable signature that can precisely predict relapse in TNBC patients after surgery. Methods: Four total cohorts of training (TCGA_TNBC and GEOD-40525) and validation (GSE40049 and GSE19783) datasets were analyzed with logistic regression and Gaussian mixture analyses. We established a miRNA signature risk model and identified an 8-miRNA signature for the prediction of TNBC relapse. Results: The miRNA signature risk model identified ten candidate miRNAs in the training set. By combining 8 of the 10 miRNAs (miR-139-5p, miR-10b-5p, miR-486-5p, miR-455-3p, miR-107, miR-146b-5p, miR-324-5p and miR-20a-5p), an accurate predictive model of relapse in TNBC patients was established and was highly correlated with prognosis (AUC of 0.80). Subsequently, this 8-miRNA signature prognosticated relapse in the two validation sets with AUCs of 0.89 and 0.90. Conclusion: The 8-miRNA signature predictive model may help clinicians provide a prognosis for TNBC patients with a high risk of recurrence after surgery and provide further personalized treatment to decrease the chance of relapse.
URI: http://dx.doi.org/10.7150/thno.46142
http://hdl.handle.net/11536/154887
ISSN: 1838-7640
DOI: 10.7150/thno.46142
期刊: THERANOSTICS
Volume: 10
Issue: 19
起始頁: 8771
結束頁: 8789
顯示於類別:期刊論文