標題: | A panel of eight microRNAs is a good predictive parameter for triple-negative breast cancer relapse |
作者: | Hong, Hsiao-Chin Chuang, Cheng-Hsun Huang, Wei-Chih Weng, Shun-Long Chen, Chia-Hung Chang, Kuang-Hsin Liao, Kuang-Wen Huang, Hsien-Da 交大名義發表 生物科技學系 生物資訊及系統生物研究所 分子醫學與生物工程研究所 National Chiao Tung University Department of Biological Science and Technology Institude of Bioinformatics and Systems Biology Institute of Molecular Medicine and Bioengineering |
關鍵字: | triple-negative breast cancer;miRNA signature;relapse;prediction;prognosis |
公開日期: | 1-一月-2020 |
摘要: | Rationale: Triple-negative breast cancer (TNBC), which has the highest recurrence rate and shortest survival time of all breast cancers, is in urgent need of a risk assessment method to determine an accurate treatment course. Recently, miRNA expression patterns have been identified as potential biomarkers for diagnosis, prognosis, and personalized therapy. Here, we investigate a combination of candidate miRNAs as a clinically applicable signature that can precisely predict relapse in TNBC patients after surgery. Methods: Four total cohorts of training (TCGA_TNBC and GEOD-40525) and validation (GSE40049 and GSE19783) datasets were analyzed with logistic regression and Gaussian mixture analyses. We established a miRNA signature risk model and identified an 8-miRNA signature for the prediction of TNBC relapse. Results: The miRNA signature risk model identified ten candidate miRNAs in the training set. By combining 8 of the 10 miRNAs (miR-139-5p, miR-10b-5p, miR-486-5p, miR-455-3p, miR-107, miR-146b-5p, miR-324-5p and miR-20a-5p), an accurate predictive model of relapse in TNBC patients was established and was highly correlated with prognosis (AUC of 0.80). Subsequently, this 8-miRNA signature prognosticated relapse in the two validation sets with AUCs of 0.89 and 0.90. Conclusion: The 8-miRNA signature predictive model may help clinicians provide a prognosis for TNBC patients with a high risk of recurrence after surgery and provide further personalized treatment to decrease the chance of relapse. |
URI: | http://dx.doi.org/10.7150/thno.46142 http://hdl.handle.net/11536/154887 |
ISSN: | 1838-7640 |
DOI: | 10.7150/thno.46142 |
期刊: | THERANOSTICS |
Volume: | 10 |
Issue: | 19 |
起始頁: | 8771 |
結束頁: | 8789 |
顯示於類別: | 期刊論文 |