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dc.contributor.authorWang, Shin-Lien_US
dc.contributor.authorHsieh, Ching-Yenen_US
dc.contributor.authorSukesan, Revathien_US
dc.contributor.authorChen, Jung-Chihen_US
dc.contributor.authorWang, Yu-Linen_US
dc.date.accessioned2020-10-05T01:59:46Z-
dc.date.available2020-10-05T01:59:46Z-
dc.date.issued2020-06-29en_US
dc.identifier.issn2162-8769en_US
dc.identifier.urihttp://dx.doi.org/10.1149/2162-8777/ab8867en_US
dc.identifier.urihttp://hdl.handle.net/11536/154893-
dc.description.abstractThis study reports the development of a rapid heavy metal ion screening tool for whole blood samples. The test system consists of an ion selective membrane-based impedance modulated field effect transistor (FET) sensor and a portable sensor measurement unit. This study focuses on the direct detection of lead ions in whole blood, without extensive sample pre-treatments. The sensing methodology is based on impedance changes in the membrane due to the specific ionophore-target metal ion interaction in the presence of a strong electric field. The changes in impedance caused by heavy metal ions are amplified by the FET to obtain a highly sensitive lead ion detection, with very low detection limit (near 10(-11) similar to 10(-10)M Pb2+). To reduce the complexity and enhance sensor performance, the whole blood samples are fractionated on chip without any external actuation/automation using simple gravitational blood cell separation. The test results in PBS, human serum and whole blood samples demonstrate high sensitivity and wide dynamic range of lead ion detection. The miniaturized extended gate FET sensor system is ideal for point of care and home-care diagnostics for heavy metal ion in blood.en_US
dc.language.isoen_USen_US
dc.subjectFETen_US
dc.subjectWhole blooden_US
dc.subjectheavy metal ionen_US
dc.subjectleaden_US
dc.subjection selective membraneen_US
dc.subjectimpedanceen_US
dc.titleHighly Sensitive Lead Ion Detection in One Drop of Human Whole Blood Using Impedance-Modulated Field-Effect Transistors and a Portable Measurement Deviceen_US
dc.typeArticleen_US
dc.identifier.doi10.1149/2162-8777/ab8867en_US
dc.identifier.journalECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGYen_US
dc.citation.volume9en_US
dc.citation.issue5en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department生醫工程研究所zh_TW
dc.contributor.departmentInstitute of Biomedical Engineeringen_US
dc.identifier.wosnumberWOS:000548794300001en_US
dc.citation.woscount0en_US
Appears in Collections:Articles