Layer-by-layer assembly and electrically controlled disassembly of water-solublePoly(3,4-ethylenedioxythiophene)derivatives for bioelectronic interface

Abstract

Poly(3,4-ethylenedioxythiophene (PEDOT) derivatives display a multitude of attractive properties such as high conductivity, biocompatibility, ease of functionalization, and high thermal stability. As a result, they show promise for applications in materials and biomedical engineering. In order to increase their applications in the practical domain, trivial fabrication techniques are required. Here, we present a simple layer-by-layer dip methodology to assemble water-soluble PEDOT derivatives that can then be disassembled via electrical stimulation. As a result, a dynamic PEDOT layered system is fabricated and could be applied as responsive materials for bioengineering. PEDOT-SO(3)and PEDOT-NMe(3)are synthesized via direct C-H arylation polymerization and chemical polymerization, respectively. The electrostatic interactions between oppositely charged SO(3)(-)and NMe(3)(+)enabled the stacking of PEDOT derivatives. The layer-by-layer assemblies are confirmed by ultraviolet-visible spectroscopy and profilometer. Morphological analyses are performed using scanning electron microscopy and atomic force microscopy, which revealed that the polymer coatings are uniform without any cracks. In situ material assembly is studied using quartz crystal microbalance, and we also demonstrate that these PEDOT-derivative assemblies can be disintegrated by electrical stimulation. Cyclic voltammetry shows a proportional increase in stored charge density with the increase in bilayer thickness, confirming stable electroactivity of these assemblies. Using this approach, we can assemble conductive bio interface on both conductive and nonconductive surfaces, expanding the capability to fabricate bioelectronic electrodes.