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dc.contributor.authorHuang, Yen-Tsungen_US
dc.contributor.authorTai, An-Shunen_US
dc.contributor.authorChou, Meng-Yingen_US
dc.contributor.authorLin, Geng-Xianen_US
dc.contributor.authorLin, Sheng-Hsuanen_US
dc.date.accessioned2020-10-05T02:02:04Z-
dc.date.available2020-10-05T02:02:04Z-
dc.date.issued1970-01-01en_US
dc.identifier.issn0277-6715en_US
dc.identifier.urihttp://dx.doi.org/10.1002/sim.8708en_US
dc.identifier.urihttp://hdl.handle.net/11536/155491-
dc.description.abstractThe sufficient component cause (SCC) model and counterfactual model are two common methods for causal inference, each with their own advantages: the SCC model allows the mechanistic interaction to be detailed, whereas the counterfactual model features a systemic framework for quantifying causal effects. Hence, integrating the SCC and counterfactual models may facilitate the conceptualization of causation. Based on the marginal SCC (mSCC) model, we propose a novel counterfactual mSCC framework that includes the steps of definition, identification, and estimation. We further propose a six-way effect decomposition for assessing mediation and the mechanistic interaction. The results demonstrate that when all variables are binary, the six-way decomposition is an extension of four-way decomposition and that without agonism, the six-way decomposition is reduced to four-way decomposition. To illustrate the utility of the proposed decomposition, we apply it to a Taiwanese cohort to examine the mechanism of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) with liver inflammation measured by alanine aminotransferase (ALT) as a mediator. Among the HCV-induced HCC cases, 62.27% are not explained by either mediation or interaction in relation to ALT; 9.32% are purely mediated by ALT; 16.53% are caused by the synergistic effect of HCV and ALT; and 9.31% are due to the mediated synergistic effect of HCV and ALT. In summary, we introduce an SCC model framework based on counterfactual theory and detail the required identification assumptions and estimation procedures; we also propose a six-way effect decomposition to unify mediation and mechanistic interaction analyses.en_US
dc.language.isoen_USen_US
dc.subjectcausal inferenceen_US
dc.subjecteffect decompositionen_US
dc.subjectinteractionen_US
dc.subjectmediationen_US
dc.subjectsufficient component causeen_US
dc.titleSix-way decomposition of causal effects: Unifying mediation and mechanistic interactionen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/sim.8708en_US
dc.identifier.journalSTATISTICS IN MEDICINEen_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department統計學研究所zh_TW
dc.contributor.departmentInstitute of Statisticsen_US
dc.identifier.wosnumberWOS:000564473000001en_US
dc.citation.woscount0en_US
Appears in Collections:Articles