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dc.contributor.authorWei, Sung-Yangen_US
dc.contributor.authorSu, Yi-Jren_US
dc.contributor.authorShih, Po-Chenen_US
dc.contributor.authorYang, Shih-Moen_US
dc.contributor.authorHsu, Longen_US
dc.date.accessioned2014-12-08T15:22:26Z-
dc.date.available2014-12-08T15:22:26Z-
dc.date.issued2010en_US
dc.identifier.isbn978-0-8194-8258-7en_US
dc.identifier.issn0277-786Xen_US
dc.identifier.urihttp://hdl.handle.net/11536/15884-
dc.identifier.urihttp://dx.doi.org/10.1117/12.860357en_US
dc.description.abstractMacrophages are members of the leukocyte family. Tissue damage causes inflammation and release of vasoactive and chemotactic factors, which trigger a local increase in blood flow and capillary permeability. Then, leukocytes accumulate quickly to the infection site. The leukocyte extravasation process takes place according to a sequence of events that involve tethering, activation by a chemoattractant stimulus, adhesion by integrin binding, and migrating to the infection site. The leukocyte extravasation process reveals that adhesion is an important part of the immune system. Optical tweezers have become a useful tool with broad applications in biology and physics. In force measurement, the trapped bead as a probe usually uses a polystyrene bead of 1 mu m diameter to measure adhesive force between the trapped beads and cell by optical tweezers. In this paper, using the ray-optics model calculated trapping stiffness and defined the linear displacement ranges. By the theoretical values of stiffness and linear displacement ranges, this study attempted to obtain a proper trapped particle size in measuring adhesive force. Finally, this work investigates real-time adhesion force measurements between human macrophages and trapped beads coated with lipopolysaccharides using optical tweezers with backscattered detection.en_US
dc.language.isoen_USen_US
dc.subjectoptical tweezersen_US
dc.subjectbackscattered detectionen_US
dc.subjectforce measurementsen_US
dc.subjectmacrophageen_US
dc.subjectlipopolysaccharidesen_US
dc.titleMeasurement of macrophage adhesion by optical tweezers with backward-scattered detectionen_US
dc.typeArticleen_US
dc.identifier.doi10.1117/12.860357en_US
dc.identifier.journalOPTICAL TRAPPING AND OPTICAL MICROMANIPULATION VIIen_US
dc.citation.volume7762en_US
dc.contributor.department電子物理學系zh_TW
dc.contributor.departmentDepartment of Electrophysicsen_US
dc.identifier.wosnumberWOS:000285837400056-
Appears in Collections:Conferences Paper


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