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dc.contributor.authorChuang, Ching-Chengen_US
dc.contributor.authorLee, Chia-Yenen_US
dc.contributor.authorChen, Chung-Mingen_US
dc.contributor.authorHsieh, Yao-Shengen_US
dc.contributor.authorLiu, Tsan-Chien_US
dc.contributor.authorSun, Chia-Weien_US
dc.date.accessioned2014-12-08T15:22:37Z-
dc.date.available2014-12-08T15:22:37Z-
dc.date.issued2012-05-01en_US
dc.identifier.issn0018-9294en_US
dc.identifier.urihttp://hdl.handle.net/11536/15999-
dc.description.abstractThis study proposed diffuser-aided diffuse optical imaging (DADOI) as a new approach to improve the performance of the conventional diffuse optical tomography (DOT) approach for breast imaging. The 3-D breast model for Monte Carlo simulation is remodeled from clinical MRI image. The modified Beer-Lambert's law is adopted with the DADOI approach to substitute the complex algorithms of inverse problem for mapping of spatial distribution, and the depth information is obtained based on the time-of-flight estimation. The simulation results demonstrate that the time-resolved Monte Carlo method can be capable of performing source-detector separations analysis. The dynamics of photon migration with various source-detector separations are analyzed for the characterization of breast tissue and estimation of optode arrangement. The source-detector separations should be less than 4 cm for breast imaging in DOT system. Meanwhile, the feasibility of DADOI was manifested in this study. In the results, DADOI approach can provide better imaging contrast and faster imaging than conventional DOT measurement. The DADOI approach possesses great potential to detect the breast tumor in early stage and chemotherapy monitoring that implies a good feasibility for clinical application.en_US
dc.language.isoen_USen_US
dc.subjectBreast tumor imagingen_US
dc.subjectdiffuse optical tomography (DOT)en_US
dc.subjectdiffuser-aided diffuse optical imaging (DADOI)en_US
dc.subjectMonte Carlo simulationen_US
dc.subjectnear-IR spectroscopyen_US
dc.subjectphoton migrationen_US
dc.titleDiffuser-Aided Diffuse Optical Imaging for Breast Tumor: A Feasibility Study Based on Time-Resolved Three-Dimensional Monte Carlo Modelingen_US
dc.typeArticleen_US
dc.identifier.journalIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERINGen_US
dc.citation.volume59en_US
dc.citation.issue5en_US
dc.citation.epage1454en_US
dc.contributor.department光電工程學系zh_TW
dc.contributor.departmentDepartment of Photonicsen_US
dc.identifier.wosnumberWOS:000303201000028-
dc.citation.woscount0-
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