Real-time Detection of alpha-Thrombin Binding to Single-Strand DNA Aptamers by a Highly Sensitive Si-Based Waveguide SPR Biosensor

doi:83512R

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DC 欄位	值	語言
dc.contributor.author	Huang, Chi-Chieh	en_US
dc.contributor.author	Hsu, Hsin-Feng	en_US
dc.contributor.author	Chen, Sz-Hau	en_US
dc.contributor.author	Tsai, Kun-Yu	en_US
dc.contributor.author	Huang, Yang-Tung	en_US
dc.contributor.author	Lin, Chih-Sheng	en_US
dc.contributor.author	Hsu, Shih-Hsin	en_US
dc.date.accessioned	2014-12-08T15:23:05Z	-
dc.date.available	2014-12-08T15:23:05Z	-
dc.date.issued	2012	en_US
dc.identifier.isbn	978-0-8194-9027-8	en_US
dc.identifier.issn	0277-786X	en_US
dc.identifier.uri	http://hdl.handle.net/11536/16228	-
dc.identifier.uri	http://dx.doi.org/83512R	en_US
dc.description.abstract	In this paper, real-time characterization of alpha-thrombin binding to single-strand DNA (ssDNA) aptamers by novel Si-based waveguide SPR biosensors has been investigated. The gold nanoparticles (AuNPs) modified with anti-thrombin antibodies were employed to bind with alpha-thrombin via strong antibody/antigen affinity for SPR signal amplification. The detection limit of 1 pM for alpha-thrombin detection was achieved.	en_US
dc.language.iso	en_US	en_US
dc.subject	SPR	en_US
dc.subject	surface plasmon resonance	en_US
dc.subject	sensor	en_US
dc.title	Real-time Detection of alpha-Thrombin Binding to Single-Strand DNA Aptamers by a Highly Sensitive Si-Based Waveguide SPR Biosensor	en_US
dc.type	Proceedings Paper	en_US
dc.identifier.doi	83512R	en_US
dc.identifier.journal	THIRD ASIA PACIFIC OPTICAL SENSORS CONFERENCE	en_US
dc.citation.volume	8351	en_US
dc.contributor.department	電子工程學系及電子研究所	zh_TW
dc.contributor.department	Department of Electronics Engineering and Institute of Electronics	en_US
dc.identifier.wosnumber	WOS:000304348500095	-
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