標題: Label-free tetra-modal molecular imaging of living cells with CARS, SHG, THG and TSFG (coherent anti-Stokes Raman scattering, second harmonic generation, third harmonic generation and third-order sum frequency generation)
作者: Segawa, Hiroki
Okuno, Masanari
Kano, Hideaki
Leproux, Philippe
Couderc, Vincent
Hamaguchi, Hiro-o
應用化學系
應用化學系分子科學碩博班
Department of Applied Chemistry
Institute of Molecular science
公開日期: 23-四月-2012
摘要: We have developed a new multimodal molecular imaging system that combines CARS (coherent anti-Stokes Raman scattering), SHG (second harmonic generation), THG (third harmonic generation) and multiplex TSFG (third-order sum frequency generation) using a subnanosecond white-light laser source. Molecular composition and their distribution in living cells are clearly visualized with different contrast enhancements through different mechanisms of CARS, SHG, THG and TSFG. A correlation image of CARS and TSF reveals that the TSF signal is generated predominantly from lipid droplets inside a cell as well as the peripheral cell wall. (C) 2012 Optical Society of America
URI: http://dx.doi.org/10.1364/OE.20.009551
http://hdl.handle.net/11536/16343
ISSN: 1094-4087
DOI: 10.1364/OE.20.009551
期刊: OPTICS EXPRESS
Volume: 20
Issue: 9
起始頁: 0
結束頁: 0
顯示於類別:期刊論文


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