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dc.contributor.authorLai, Yan-Longen_US
dc.contributor.authorChen, Chih-Chiehen_US
dc.contributor.authorHwang, Jenn-Kangen_US
dc.date.accessioned2014-12-08T15:23:54Z-
dc.date.available2014-12-08T15:23:54Z-
dc.date.issued2012-07-01en_US
dc.identifier.issn0305-1048en_US
dc.identifier.urihttp://hdl.handle.net/11536/16637-
dc.description.abstract"Knotted proteins have recently received lots of attention due to their interesting topological novelty as well as its puzzling folding mechanisms. We previously published a pKNOT server, which provides a structural database of knotted proteins, analysis tools for detecting and analyzing knotted regions from structures as well as a Java-based 3D graphics viewer for visualizing knotted structures. However, there lacks a convenient platform performing similar tasks directly from 'protein sequences'. In the current version of the web server, referred to as pKNOT v.2, we implement a homology modeling tool such that the server can now accept protein sequences in addition to 3D structures or Protein Data Bank (PDB) IDs and return knot analysis. In addition, we have updated the database of knotted proteins from the current PDB with a combination of automatic and manual procedure. We believe that the updated pKNOT server with its extended functionalities will provide better service to biologists interested in the research of knotted proteins. The pKNOT v.2 is available from http://pknot.life.nctu.edu.tw/."en_US
dc.language.isoen_USen_US
dc.titlepKNOT v.2: the protein KNOT web serveren_US
dc.typeArticleen_US
dc.identifier.journalNUCLEIC ACIDS RESEARCHen_US
dc.citation.volume40en_US
dc.citation.issueW1en_US
dc.citation.epageW228en_US
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000306670900037-
dc.citation.woscount5-
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