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dc.contributor.authorWu, Gideon C. -T.en_US
dc.contributor.authorChen, Feng-Chien_US
dc.date.accessioned2014-12-08T15:23:58Z-
dc.date.available2014-12-08T15:23:58Z-
dc.date.issued2012en_US
dc.identifier.issn1176-9343en_US
dc.identifier.urihttp://hdl.handle.net/11536/16676-
dc.description.abstract"What causes the variations in evolutionary rates is fundamental to molecular evolution. However, in plants, the causes of within-gene evolutionary rate variations remain underexplored. Here we use the principal component regression to examine the contributions of eleven exon features to the within-gene variations in nonsynonymous substitution rate (d(N)), synonymous substitution rate (d(S)), and the d(N)/d(S) ratio in Arabidopsis species. We demonstrate that exon features related to protein structural-functional constraints and mRNA splicing account for the largest proportions of within-gene variations in d(N)/d(S) and d(N). Meanwhile, for d(S), a combination of expression level, exon length, and structural-functional features explains the largest proportion of within-gene variances. Our results suggest that the determinants of within-gene variations differ from those of between-gene variations in evolutionary rates. Furthermore, the relative importance of different exon features also differs between plants and animals. Our study thus may shed a new light on the evolution of plant genes."en_US
dc.language.isoen_USen_US
dc.subjectexonic evolutionary ratesen_US
dc.subjectnonsynonymous substitution rateen_US
dc.subjectsynonymous substitution rateen_US
dc.subjectprincipal component regressionen_US
dc.subjectArabidopsis thalianaen_US
dc.titleDeterminants of Exon-Level Evolutionary Rates in Arabidopsis Speciesen_US
dc.typeArticleen_US
dc.identifier.journalEVOLUTIONARY BIOINFORMATICSen_US
dc.citation.volume8en_US
dc.citation.epage389en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000306642700001-
dc.citation.woscount3-
Appears in Collections:Articles


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