Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wu, Gideon C. -T. | en_US |
dc.contributor.author | Chen, Feng-Chi | en_US |
dc.date.accessioned | 2014-12-08T15:23:58Z | - |
dc.date.available | 2014-12-08T15:23:58Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.issn | 1176-9343 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/16676 | - |
dc.description.abstract | "What causes the variations in evolutionary rates is fundamental to molecular evolution. However, in plants, the causes of within-gene evolutionary rate variations remain underexplored. Here we use the principal component regression to examine the contributions of eleven exon features to the within-gene variations in nonsynonymous substitution rate (d(N)), synonymous substitution rate (d(S)), and the d(N)/d(S) ratio in Arabidopsis species. We demonstrate that exon features related to protein structural-functional constraints and mRNA splicing account for the largest proportions of within-gene variations in d(N)/d(S) and d(N). Meanwhile, for d(S), a combination of expression level, exon length, and structural-functional features explains the largest proportion of within-gene variances. Our results suggest that the determinants of within-gene variations differ from those of between-gene variations in evolutionary rates. Furthermore, the relative importance of different exon features also differs between plants and animals. Our study thus may shed a new light on the evolution of plant genes." | en_US |
dc.language.iso | en_US | en_US |
dc.subject | exonic evolutionary rates | en_US |
dc.subject | nonsynonymous substitution rate | en_US |
dc.subject | synonymous substitution rate | en_US |
dc.subject | principal component regression | en_US |
dc.subject | Arabidopsis thaliana | en_US |
dc.title | Determinants of Exon-Level Evolutionary Rates in Arabidopsis Species | en_US |
dc.type | Article | en_US |
dc.identifier.journal | EVOLUTIONARY BIOINFORMATICS | en_US |
dc.citation.volume | 8 | en_US |
dc.citation.epage | 389 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.identifier.wosnumber | WOS:000306642700001 | - |
dc.citation.woscount | 3 | - |
Appears in Collections: | Articles |
Files in This Item:
If it is a zip file, please download the file and unzip it, then open index.html in a browser to view the full text content.