标题: | VIP DB - A viral protein domain usage and distribution database |
作者: | Chen, Ting-Wen Gan, Richie Ruei-Chi Wu, Timothy H. Lin, Wen-Chang Tang, Petrus 生物科技学系 Department of Biological Science and Technology |
关键字: | Protein domain;Domain-domain interaction;Viral protein interaction;Protein annotation |
公开日期: | 1-九月-2012 |
摘要: | During the viral infection and replication processes, viral proteins are highly regulated and may interact with host proteins. However, the functions and interaction partners of many viral proteins have yet to be explored. Here, we compiled a Viral Protein domain DataBase (VIP DB) to associate viral proteins with putative functions and interaction partners. We systematically assign domains and infer the functions of proteins and their protein interaction partners from their domain annotations. A total of 2,322 unique domains that were identified from 2,404 viruses are used as a starting point to correlate GO classification, KEGG metabolic pathway annotation and domain-domain interactions. Of the unique domains, 42.7% have GO records, 39.6% have at least one domain-domain interaction record and 26.3% can also be found in either mammals or plants. This database provides a resource to help virologists identify potential roles for viral protein. All of the information is available at http://vipdb.cgu.edu.tw. (C) 2012 Elsevier Inc. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.ygeno.2012.06.008 http://hdl.handle.net/11536/16874 |
ISSN: | 0888-7543 |
DOI: | 10.1016/j.ygeno.2012.06.008 |
期刊: | GENOMICS |
Volume: | 100 |
Issue: | 3 |
起始页: | 149 |
结束页: | 156 |
显示于类别: | Articles |
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