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dc.contributor.authorHuang, Chen-Hsien_US
dc.contributor.authorHsiao, Pai-Yien_US
dc.contributor.authorTseng, Fan-Gangen_US
dc.contributor.authorFan, Shih-Kangen_US
dc.contributor.authorFu, Chien-Chungen_US
dc.contributor.authorPan, Rong-Longen_US
dc.date.accessioned2014-12-08T15:26:22Z-
dc.date.available2014-12-08T15:26:22Z-
dc.date.issued2011-10-04en_US
dc.identifier.issn0743-7463en_US
dc.identifier.urihttp://dx.doi.org/10.1021/la201977den_US
dc.identifier.urihttp://hdl.handle.net/11536/18717-
dc.description.abstractWe study the indentation of a free-standing lipid membrane suspended over a nanopore on a hydrophobic substrate by means of molecular dynamics simulations. We find that in the course of indentation the membrane bends at the point of contact and the fringes of the membrane glide downward intermittently along the pore edges and stop gliding when the fringes reach the edge bottoms. The bending continues afterward, and the large strain eventually induces a phase transition in the membrane, transformed from a bilayered structure to an interdigitated structure. The membrane is finally ruptured when the indentation goes deep enough. Several local physical quantities in the pore regions are calculated, which include the tilt angle of lipid molecules, the nematic order, the included angle, and the distance between neighboring lipids. The variations of the;e quantities reveal many detailed, not-yet-specified local structural transitions of lipid molecules under indentation. The force indentation curve is also studied and discussed. The results make a connection between the microscopic structure and the macroscopic properties and provide deep insight into the understanding of the stability of a lipid membrane spanning over nanopore.en_US
dc.language.isoen_USen_US
dc.titlePore-Spanning Lipid Membrane under Indentation by a Probe Tip: A Molecular Dynamics Simulation Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/la201977den_US
dc.identifier.journalLANGMUIRen_US
dc.citation.volume27en_US
dc.citation.issue19en_US
dc.citation.spage11930en_US
dc.citation.epage11942en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000295187300028-
dc.citation.woscount4-
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