Title: | Expression Status of Ribonucleotide Reductase Small Subunits hRRM2/p53R2 as Prognostic Biomarkers in Stage I and II Non-small Cell Lung Cancer |
Authors: | Hsu, Nan-Yung Wu, Jeng-Yuan Liu, Xiyong Yen, Yun Chen, Chih-Yi Chou, Ming-Chih Lin, Chun-Hsuan Lee, Huei Cheng, Ya-Wen 生物科技學系 Department of Biological Science and Technology |
Keywords: | Non-small cell lung cancer;ribonucleotide reductase;p53R2;hRRM2 |
Issue Date: | 1-Oct-2011 |
Abstract: | Overexpression of ribonucleotide reductase M2 (hRRM2) and p53-dependent RR small subunit (p53R2) has been correlated with tumor malignancy and progression in several types of cancer. The aim of this study was to determine the association of p53R2/hRRM2 expression with clinicopathological characteristics of stage I and II non-small cell lung cancer (NSCLC). Immunohistochemistry was conducted on a tissue array that included 92 samples. Correlations between hRRM2 and p53R2 expression and clinicopathological factors, recurrence/metastasis, and outcomes were analyzed. The analyses revealed that there was no correlation between p53R2 expression and clinicopathological factors; hRRM2 was only positively related to poor tumor differentiation (p=0.006). Regarding overall survival during the follow-up period, patients with p53R2+/hRRM2- tumors had the best outcomes (p<0.01). Multivariant Cox analysis revealed that p53R2 (risk=0.232, 95% CI=0.086-0.626, p=0.004) not only served as a prognostic biomarker to predict survival, but also as an independent biomarker to predict disease-free survival (risk=0.545, 95% CI=0.301-0.987, p=0.045) of patients with NSCLC. Therefore, we consider that the expression of p53R2 can be used not only as a biomarker for overall survival, but also as an indicator for tumor recurrence. Based on our finding, p53R2 expression seems more important than that of hRRM2 in prognosis of early-stage lung cancer. |
URI: | http://hdl.handle.net/11536/18749 |
ISSN: | 0250-7005 |
Journal: | ANTICANCER RESEARCH |
Volume: | 31 |
Issue: | 10 |
Begin Page: | 3475 |
End Page: | 3481 |
Appears in Collections: | Articles |
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