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dc.contributor.authorWang, Hsiuyingen_US
dc.date.accessioned2014-12-08T15:27:46Z-
dc.date.available2014-12-08T15:27:46Z-
dc.date.issued2011-09-01en_US
dc.identifier.issn1055-7903en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.ympev.2011.05.013en_US
dc.identifier.urihttp://hdl.handle.net/11536/20025-
dc.description.abstractIn the nucleotide substitution model for molecular evolution, a major task in the exploration of an evolutionary process is to estimate the substitution number per site of a protein or DNA sequence. The usual estimators are based on the observation of the difference proportion of the two nucleotide sequences. However, a more objective approach is to report a confidence interval with precision rather than only providing point estimators. The conventional confidence intervals used in the literature for the substitution number are constructed by the normal approximation. The performance and construction of confidence intervals for evolutionary models have not been much investigated in the literature. In this article, the performance of these conventional confidence intervals for one-parameter and two-parameter models are explored. Results show that the coverage probabilities of these intervals are unsatisfactory when the true substitution number is small. Since the substitution number may be small in many situations for an evolutionary process, the conventional confidence interval cannot provide accurate information for these cases. Improved confidence intervals for the one-parameter model with desirable coverage probability are proposed in this article. A numerical calculation shows the substantial improvement of the new confidence intervals over the conventional confidence intervals. (C) 2011 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectOne-parameter modelen_US
dc.subjectTwo-parameter modelen_US
dc.subjectConfidence intervalen_US
dc.subjectCoverage probabilityen_US
dc.subjectBinomial distributionen_US
dc.subjectSubstitution rateen_US
dc.titleConfidence intervals for the substitution number in the nucleotide substitution modelsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ympev.2011.05.013en_US
dc.identifier.journalMOLECULAR PHYLOGENETICS AND EVOLUTIONen_US
dc.citation.volume60en_US
dc.citation.issue3en_US
dc.citation.spage472en_US
dc.citation.epage479en_US
dc.contributor.department統計學研究所zh_TW
dc.contributor.departmentInstitute of Statisticsen_US
dc.identifier.wosnumberWOS:000292580200018-
dc.citation.woscount1-
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