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dc.contributor.authorLiao, Kuang-Wenen_US
dc.contributor.authorLin, Chen-Sien_US
dc.contributor.authorChen, Wen-Liangen_US
dc.contributor.authorYang, Chu-Tingen_US
dc.contributor.authorLin, Ching-Minen_US
dc.contributor.authorHsu, Wei-Tungen_US
dc.contributor.authorLin, Yi-Yinen_US
dc.contributor.authorChiu, Yi-Hanen_US
dc.contributor.authorHuang, Kuo-Chinen_US
dc.contributor.authorWu, Hsin-Yien_US
dc.contributor.authorWu, Ming-Shiangen_US
dc.contributor.authorWu, Chang-Jeren_US
dc.contributor.authorMao, Simon Jen-Tanen_US
dc.contributor.authorTsai, Nu-Manen_US
dc.date.accessioned2014-12-08T15:29:08Z-
dc.date.available2014-12-08T15:29:08Z-
dc.date.issued2011-08-01en_US
dc.identifier.issn1043-4666en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.cyto.2011.04.011en_US
dc.identifier.urihttp://hdl.handle.net/11536/21004-
dc.description.abstractAnti-Helicobacter pylori heat shock protein 60 (HpHSP60) antibodies are Usually found in H. pylori-infected patients and are known to be associated with the progression of gastric diseases. However, the effects of these antibodies on the functions of HpHSP60 have not been identified. This study aims to investigate the effects of the interaction between anti-HSP60 antibodies and HpHSP60 on inflammatory responses. Anti-HpHSP60 polyclonal sera and monoclonal antibodies (mAbs) were produced to evaluate their effects on HpHSP60-induced IL-8 and TNF-alpha activity. The results indicated that anti-HpHSP60 polyclonal sera collected from patients infected with H. pylori or from rabbit and mice immunized with HpHSP60 could significantly enhance HpHSP60-mediated IL-8 and TNF-alpha secretion from monocytic THP-1 cells. Similar effects were also found with anti-HpHSP60 mAbs. Further analysis revealed that this phenomenon was only carried out by anti-HpHSP60 antibody but not by other non-specific mAbs. Moreover, the non-specific mAbs decreased the synergism of HpHSP60 and anti-HpHSP60 mAbs in proinflammatory cytokine induction. Herein, we have examined the role of anti-HpHSP60 antibody in host immune responses for the first time. This study demonstrated that H. pylori HSP60/mAbs could modulate helico-bacterial pathogenesis by increasing IL-8 and TNF-alpha production. The pathogen-specific antibodies may execute potential immune functions rather than recognize or neutralize microbes. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectHelicobacter pylorien_US
dc.subjectHeat shock protein 60en_US
dc.subjectAnti-HpHSP60 antibodyen_US
dc.subjectIL-8en_US
dc.subjectTNF-alphaen_US
dc.titleAntibodies against Helicobacter pylori heat shock protein 60 aggravate HSP60-mediated proinflammatory responsesen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.cyto.2011.04.011en_US
dc.identifier.journalCYTOKINEen_US
dc.citation.volume55en_US
dc.citation.issue2en_US
dc.citation.spage174en_US
dc.citation.epage180en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000293158100004-
dc.citation.woscount2-
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