完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tsai, Kun-Hsi | en_US |
dc.contributor.author | Hsien, Hau-Hsueh | en_US |
dc.contributor.author | Chen, Li-Mien | en_US |
dc.contributor.author | Ting, Wei-Jen | en_US |
dc.contributor.author | Yang, Yuh-Shyong | en_US |
dc.contributor.author | Kuo, Chia-Hua | en_US |
dc.contributor.author | Tsai, Chang-Hai | en_US |
dc.contributor.author | Tsai, Fuu-Jen | en_US |
dc.contributor.author | Tsai, Henry J. | en_US |
dc.contributor.author | Huang, Chih-Yang | en_US |
dc.date.accessioned | 2014-12-08T15:29:22Z | - |
dc.date.available | 2014-12-08T15:29:22Z | - |
dc.date.issued | 2013-05-01 | en_US |
dc.identifier.issn | 0308-8146 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1016/j.foodchem.2012.10.038 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/21152 | - |
dc.description.abstract | The aim of our study was to investigate the mechanisms by which rhubarb regulates beta-catenin as well as metastasis of hepatocellular carcinomas. Our results revealed that rhubarb extract inhibited HA22T cell migration ability in wound healing, migration and invasion assays in a dose-dependent manner. Rhubarb also reduced beta-catenin protein level, downregulated its downstream proteins, cyclin D, Tbx3 and c-Myc, and attenuated the expression of MMP9 and contactin-1 metastatic factors. Additionally, rhubarb inhibited beta-catenin nuclear accumulation and induced its degradation via proteasome-mediated pathway. Furthermore, we found that rhubarb suppressed the p-ser(9) GSK-3-beta protein level to inactivate Wnt signalling and reduce beta-catenin protein level. Taken together; we found that rhubarb blocked the metastatic process of HA22T hepatocellular carcinoma cells mediated through GSK-3-beta activation, and enhancement of protein degradation as well as reduction of the nuclear accumulation of beta-catenin. (C) 2012 Elsevier Ltd. All rights reserved. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Rhubarb | en_US |
dc.subject | Hepatocellular carcinoma (HCC) | en_US |
dc.subject | GSK-3-beta | en_US |
dc.subject | beta-Catenin | en_US |
dc.title | Rhubarb inhibits hepatocellular carcinoma cell metastasis via GSK-3-beta activation to enhance protein degradation and attenuate nuclear translocation of beta-catenin | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.foodchem.2012.10.038 | en_US |
dc.identifier.journal | FOOD CHEMISTRY | en_US |
dc.citation.volume | 138 | en_US |
dc.citation.issue | 1 | en_US |
dc.citation.spage | 278 | en_US |
dc.citation.epage | 285 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.identifier.wosnumber | WOS:000314193800042 | - |
dc.citation.woscount | 0 | - |
顯示於類別: | 期刊論文 |