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dc.contributor.authorTsai, Kun-Hsien_US
dc.contributor.authorHsien, Hau-Hsuehen_US
dc.contributor.authorChen, Li-Mienen_US
dc.contributor.authorTing, Wei-Jenen_US
dc.contributor.authorYang, Yuh-Shyongen_US
dc.contributor.authorKuo, Chia-Huaen_US
dc.contributor.authorTsai, Chang-Haien_US
dc.contributor.authorTsai, Fuu-Jenen_US
dc.contributor.authorTsai, Henry J.en_US
dc.contributor.authorHuang, Chih-Yangen_US
dc.date.accessioned2014-12-08T15:29:22Z-
dc.date.available2014-12-08T15:29:22Z-
dc.date.issued2013-05-01en_US
dc.identifier.issn0308-8146en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.foodchem.2012.10.038en_US
dc.identifier.urihttp://hdl.handle.net/11536/21152-
dc.description.abstractThe aim of our study was to investigate the mechanisms by which rhubarb regulates beta-catenin as well as metastasis of hepatocellular carcinomas. Our results revealed that rhubarb extract inhibited HA22T cell migration ability in wound healing, migration and invasion assays in a dose-dependent manner. Rhubarb also reduced beta-catenin protein level, downregulated its downstream proteins, cyclin D, Tbx3 and c-Myc, and attenuated the expression of MMP9 and contactin-1 metastatic factors. Additionally, rhubarb inhibited beta-catenin nuclear accumulation and induced its degradation via proteasome-mediated pathway. Furthermore, we found that rhubarb suppressed the p-ser(9) GSK-3-beta protein level to inactivate Wnt signalling and reduce beta-catenin protein level. Taken together; we found that rhubarb blocked the metastatic process of HA22T hepatocellular carcinoma cells mediated through GSK-3-beta activation, and enhancement of protein degradation as well as reduction of the nuclear accumulation of beta-catenin. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectRhubarben_US
dc.subjectHepatocellular carcinoma (HCC)en_US
dc.subjectGSK-3-betaen_US
dc.subjectbeta-Cateninen_US
dc.titleRhubarb inhibits hepatocellular carcinoma cell metastasis via GSK-3-beta activation to enhance protein degradation and attenuate nuclear translocation of beta-cateninen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.foodchem.2012.10.038en_US
dc.identifier.journalFOOD CHEMISTRYen_US
dc.citation.volume138en_US
dc.citation.issue1en_US
dc.citation.spage278en_US
dc.citation.epage285en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000314193800042-
dc.citation.woscount0-
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