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dc.contributor.authorLi, W. -M.en_US
dc.contributor.authorChen, S. -Y.en_US
dc.contributor.authorLiu, D. -M.en_US
dc.date.accessioned2014-12-08T15:29:31Z-
dc.date.available2014-12-08T15:29:31Z-
dc.date.issued2013-02-01en_US
dc.identifier.issn1742-7061en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.actbio.2012.09.023en_US
dc.identifier.urihttp://hdl.handle.net/11536/21233-
dc.description.abstractAn amphiphilic gelatin-iron oxide core/calcium phosphate shell (AGIO@CaP-DOX) nanoparticle was successfully synthesized as an efficient anti-cancer drug delivery system, where doxorubicin (DOX) as a model molecule was encapsulated by electrolytic co-deposition during CaP shell formation. The shell of CaP precipitate played a pivotal role, not only in acting as a drug depot, but also in rendering the drug release rate in a highly pH-dependent controlled manner. Together with MR imaging, highly biocompatible drug-carrying CaP shell and efficient cellular internalization, the AGIO@CaP-DOX nanoparticles developed in this study area promising multifunctional nanodevice for nanotherapeutic approaches. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectCalcium phosphateen_US
dc.subjectpH-sensitivityen_US
dc.subjectDrug releaseen_US
dc.subjectAmphiphilic gelatinen_US
dc.subjectMR imagingen_US
dc.titleIn situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imagingen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.actbio.2012.09.023en_US
dc.identifier.journalACTA BIOMATERIALIAen_US
dc.citation.volume9en_US
dc.citation.issue2en_US
dc.citation.spage5360en_US
dc.citation.epage5368en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000315170800045-
dc.citation.woscount14-
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