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dc.contributor.authorChen, Yu-Chieen_US
dc.contributor.authorUrban, Pawel L.en_US
dc.date.accessioned2014-12-08T15:30:24Z-
dc.date.available2014-12-08T15:30:24Z-
dc.date.issued2013-03-01en_US
dc.identifier.issn0165-9936en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.trac.2012.11.010en_US
dc.identifier.urihttp://hdl.handle.net/11536/21743-
dc.description.abstractMass spectrometry (MS) offers advantages over conventional spectroscopic assays because it enables structural determination of reactants while preserving temporal resolution. The ability to detect short-lived reaction intermediates or labile metabolites makes time-resolved MS (TRMS) measurements an enabling tool for studies of chemical reactions, chemical kinetics and biochemical dynamics. High temporal resolution requires careful optimization of the interface, which would enable quenching of the chemical process, ionization and rapid transfer of the analytes into the mass analyzer. We review recent advances in TRMS, and outline the prospects for future developments and applications. (c) 2013 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectBiochemical dynamicsen_US
dc.subjectChemical reactionen_US
dc.subjectFast processen_US
dc.subjectKinetic measurementen_US
dc.subjectMass spectrometryen_US
dc.subjectReaction intermediateen_US
dc.subjectReaction monitoringen_US
dc.subjectStructural determinationen_US
dc.subjectTemporal resolutionen_US
dc.subjectTime-resolved mass spectrometryen_US
dc.titleTime-resolved mass spectrometryen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.trac.2012.11.010en_US
dc.identifier.journalTRAC-TRENDS IN ANALYTICAL CHEMISTRYen_US
dc.citation.volume44en_US
dc.citation.issueen_US
dc.citation.spage106en_US
dc.citation.epage120en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000317148800018-
dc.citation.woscount9-
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