Full metadata record
DC FieldValueLanguage
dc.contributor.authorChang, Chi-Chenen_US
dc.contributor.authorKuan, Tang-Chingen_US
dc.contributor.authorHsieh, Yao-Yuanen_US
dc.contributor.authorHo, Ying-Juien_US
dc.contributor.authorSun, Yu-Lingen_US
dc.contributor.authorLin, Chih-Shengen_US
dc.date.accessioned2014-12-08T15:30:31Z-
dc.date.available2014-12-08T15:30:31Z-
dc.date.issued2011en_US
dc.identifier.issn1449-2288en_US
dc.identifier.urihttp://hdl.handle.net/11536/21804-
dc.description.abstractDiosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old female Wistar rats with bilateral OVX or sham operation (controls) were divided and administered different dosages of diosgenin (0, 10, 50, or 100 mg/kg/day) for 8 weeks. Serum was then sampled for progesterone (P4) and estradiol (E2) assay and uterine horns harvested. Myometrial MMP-2 and -9 activity and expression were surveyed and myometrial collagen expression was also assayed. The results show higher body weight in OVX rats across the 8 weeks post surgery and no significant differences were noted among OVX or Sham rats with diosgenin supplements. There were lower P4 and E2 concentrations in OVX rats compared to Sham rats, and higher P4 concentration of Sham rats post diosgenin supplement. MMP-2 and -9 mRNA expression and activity was lower in OVX rats, although higher MMP-2 and lower MMP-9 activity/mRNA expression was observed in OVX rats post diosgenin supplementation. Collagen mRNA expression was higher in OVX rats compared to Sham controls, and diosgenin administration decreased collagen mRNA expression in OVX rats. In conclusion, diosgenin is associated with gelatinase expression and collagen metabolism in OVX rats. Diosgenin administration can partially reverse the effects of OVX upon MMP functions and hormone status. Adequate diosgenin supplement might modulate myometrial gelatinase expression and collagen metabolism in menopausal subjects.en_US
dc.language.isoen_USen_US
dc.subjectdiosgeninen_US
dc.subjectgelatinaseen_US
dc.subjectmatrix metalloproteinaseen_US
dc.subjectmyometriumen_US
dc.subjectovariectomizationen_US
dc.titleEffects of Diosgenin on Myometrial Matrix Metalloproteinase-2 and-9 Activity and Expression in Ovariectomized Ratsen_US
dc.typeArticleen_US
dc.identifier.journalINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCESen_US
dc.citation.volume7en_US
dc.citation.issue6en_US
dc.citation.spage837en_US
dc.citation.epage847en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000208687900002-
dc.citation.woscount6-
Appears in Collections:Articles


Files in This Item:

  1. 000208687900002.pdf

If it is a zip file, please download the file and unzip it, then open index.html in a browser to view the full text content.