標題: | The zona incerta modulates spontaneous spike-wave discharges in the rat |
作者: | Shaw, Fu-Zen Liao, Yi-Fang Chen, Ruei-Feng Huang, Yu-Hsing Lin, Rick C. S. 友訊交大聯合研發中心 D Link NCTU Joint Res Ctr |
關鍵字: | zona incerta;absence seizure;spike-wave discharge;tremor;deep brain stimulation |
公開日期: | 1-五月-2013 |
摘要: | The contribution of the zona incerta (ZI) of the thalamus on spike-wave discharges (SWDs) was investigated. Chronic recordings of bilateral cortices, bilateral vibrissa muscle, and unilateral ZI were performed in Long-Evans rats to examine the functional role of SWDs. Rhythmic ZI activity appeared at the beginning of SWD and was accompanied by higher-oscillation frequencies and larger spike magnitudes. Bilateral lidocaine injections into the mystacial pads led to a decreased oscillation frequency of SWDs, but the phenomenon of ZI-related spike magnitude enhancement was preserved. Moreover, 800-Hz ZI microstimulation terminates most of the SWDs and whisker twitching (WT; >80%). In contrast, 200-Hz ZI microstimulation selectively stops WTs but not SWDs. Stimulation of the thalamic ventroposteriomedial nucleus showed no obvious effect on terminating SWDs. A unilateral ZI lesion resulted in a significant reduction of 7- to 12-Hz power of both the ipsilateral cortical and contralateral vibrissae muscle activities during SWDs. Intraincertal microinfusion of muscimol showed a significant inhibition on SWDs. Our present data suggest that the ZI actively modulates the SWD magnitude and WT behavior. |
URI: | http://dx.doi.org/10.1152/jn.00750.2011 http://hdl.handle.net/11536/21895 |
ISSN: | 0022-3077 |
DOI: | 10.1152/jn.00750.2011 |
期刊: | JOURNAL OF NEUROPHYSIOLOGY |
Volume: | 109 |
Issue: | 10 |
起始頁: | 2505 |
結束頁: | 2516 |
顯示於類別: | 期刊論文 |