Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shaw, Fu-Zen | en_US |
dc.contributor.author | Liao, Yi-Fang | en_US |
dc.contributor.author | Chen, Ruei-Feng | en_US |
dc.contributor.author | Huang, Yu-Hsing | en_US |
dc.contributor.author | Lin, Rick C. S. | en_US |
dc.date.accessioned | 2014-12-08T15:30:40Z | - |
dc.date.available | 2014-12-08T15:30:40Z | - |
dc.date.issued | 2013-05-01 | en_US |
dc.identifier.issn | 0022-3077 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1152/jn.00750.2011 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/21895 | - |
dc.description.abstract | The contribution of the zona incerta (ZI) of the thalamus on spike-wave discharges (SWDs) was investigated. Chronic recordings of bilateral cortices, bilateral vibrissa muscle, and unilateral ZI were performed in Long-Evans rats to examine the functional role of SWDs. Rhythmic ZI activity appeared at the beginning of SWD and was accompanied by higher-oscillation frequencies and larger spike magnitudes. Bilateral lidocaine injections into the mystacial pads led to a decreased oscillation frequency of SWDs, but the phenomenon of ZI-related spike magnitude enhancement was preserved. Moreover, 800-Hz ZI microstimulation terminates most of the SWDs and whisker twitching (WT; >80%). In contrast, 200-Hz ZI microstimulation selectively stops WTs but not SWDs. Stimulation of the thalamic ventroposteriomedial nucleus showed no obvious effect on terminating SWDs. A unilateral ZI lesion resulted in a significant reduction of 7- to 12-Hz power of both the ipsilateral cortical and contralateral vibrissae muscle activities during SWDs. Intraincertal microinfusion of muscimol showed a significant inhibition on SWDs. Our present data suggest that the ZI actively modulates the SWD magnitude and WT behavior. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | zona incerta | en_US |
dc.subject | absence seizure | en_US |
dc.subject | spike-wave discharge | en_US |
dc.subject | tremor | en_US |
dc.subject | deep brain stimulation | en_US |
dc.title | The zona incerta modulates spontaneous spike-wave discharges in the rat | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1152/jn.00750.2011 | en_US |
dc.identifier.journal | JOURNAL OF NEUROPHYSIOLOGY | en_US |
dc.citation.volume | 109 | en_US |
dc.citation.issue | 10 | en_US |
dc.citation.spage | 2505 | en_US |
dc.citation.epage | 2516 | en_US |
dc.contributor.department | 友訊交大聯合研發中心 | zh_TW |
dc.contributor.department | D Link NCTU Joint Res Ctr | en_US |
dc.identifier.wosnumber | WOS:000319121400007 | - |
dc.citation.woscount | 1 | - |
Appears in Collections: | Articles |