标题: | Increased risk of deep neck infection among HIV-infected patients in the era of highly active antiretroviral therapy-a population-based follow-up study |
作者: | Liu, Ching-Feng Weng, Shih-Feng Lin, Yung-Song Lin, Chih-Sheng Lien, Ching-Feng Wang, Jhi-Joung 生物科技學系 Department of Biological Science and Technology |
关键字: | Deep neck infection;HIV;Highly active antiretroviral therapy |
公开日期: | 22-四月-2013 |
摘要: | Background: Deep neck infections (DNIs) in HIV-infected patients often produce severe complications, even death. Data on the incidence rates and risks of DNI among HIV-infected patients are scarce, particularly with the widespread use of highly active antiretroviral therapy (HAART). We evaluated the incidence rates and risks for DNI among HIV-infected patients and observed the long-term trends. Methods: A total of 9888 new HIV-infected patients diagnosed in 2001-2007 were included and matched with 49440 randomly selected subjects. The HIV-infected subjects were offered free access to HAART. All subjects were traced until December 2009. A Kaplan-Meier analysis generated the cumulative DNI incidence rate. The adjusted hazard ratio was computed using Cox proportional hazard regressions. Results: From the HIV-infected and comparison cohorts, 222 individuals (57.01 cases per 10000 person-years) and 735 individuals (35.54 cases per 10000 person-years) developed DNI, respectively. The log rank test indicated that patients with HIV had a significantly higher 8-year incidence rate of DNI than the control group (P < 0.0001). The adjusted hazard ratio for developing DNI after an HIV attack during the mean 3.94 years follow-up period was 1.59. The incidence rate and relative risk of DNI were 74.58 (per 10000 person-years) and 2.05 (P < 0.0001). Both figures were highest in the first follow-up year and decreased year-by-year thereafter. Conclusion: The risk of developing DNI is significantly elevated among HIV-infected patients, even with free access to HAART. Additional research is needed to examine the role of HAART in reducing the risk. |
URI: | http://dx.doi.org/10.1186/1471-2334-13-183 http://hdl.handle.net/11536/21927 |
ISSN: | 1471-2334 |
DOI: | 10.1186/1471-2334-13-183 |
期刊: | BMC INFECTIOUS DISEASES |
Volume: | 13 |
Issue: | |
结束页: | |
显示于类别: | Articles |
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