標題: | Multicomponent Solvent-Free Synthesis Of Benzimidazolyl Imidazo[1,2-a]-pyridine Under Microwave Irradiation |
作者: | Maiti, Barnali Chanda, Kaushik Selvaraju, Manikandan Tseng, Chih-Chung Sun, Chung-Ming 應用化學系 Department of Applied Chemistry |
關鍵字: | microwave irradiation;benzimidazole-imidazo[1,2-a]pyridines;solvent-free;bis-heterocyclic skeletons;three-component reaction |
公開日期: | 1-六月-2013 |
摘要: | A novel one-pot, three-component reaction employing variously substituted benzimidazole-linked amino pyridines, aldehydes, and isonitriles catalyzed by scandium(III) triflate under solvent-free conditions were accomplished. This new synthetic methodology facilitates the rapid generation of intricate molecular frameworks in three-dimensional fashion leading to benzinaidazole-imidazo [1,2-a] pyridines. This approach is envisioned as an environmentally benign process and a simple operation to the biological interesting compounds. The present synthetic sequence permits the introduction of three points of structural diversity to expand chemical space with high purity and excellent yields. |
URI: | http://dx.doi.org/10.1021/co400010y http://hdl.handle.net/11536/22329 |
ISSN: | 2156-8952 |
DOI: | 10.1021/co400010y |
期刊: | ACS COMBINATORIAL SCIENCE |
Volume: | 15 |
Issue: | 6 |
起始頁: | 291 |
結束頁: | 297 |
顯示於類別: | 期刊論文 |