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dc.contributor.authorLin, Chien-Hungen_US
dc.contributor.authorChang, Tsung-Cheen_US
dc.contributor.authorDas, Anindyaen_US
dc.contributor.authorFang, Ming-Yuen_US
dc.contributor.authorHung, Hui-Chenen_US
dc.contributor.authorHsu, Kai-Chengen_US
dc.contributor.authorYang, Jinn-Moonen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.contributor.authorMong, Kwok Kong T.en_US
dc.contributor.authorHsu, Tsu-Anen_US
dc.contributor.authorLin, Chun-Chengen_US
dc.date.accessioned2014-12-08T15:31:44Z-
dc.date.available2014-12-08T15:31:44Z-
dc.date.issued2013en_US
dc.identifier.issn1477-0520en_US
dc.identifier.urihttp://hdl.handle.net/11536/22456-
dc.identifier.urihttp://dx.doi.org/10.1039/c3ob40624een_US
dc.description.abstractA series of acylguanidine-modified zanamivir analogs were synthesized and their inhibitory activities against the NAs of avian influenza viruses (H1N1 and H3N2) were evaluated. In particular, zanamivir derivative 3j, with a hydrophobic naphthalene substituent, exhibits the best inhibitory activity against group-1 NA with an IC50 of 20 nM.en_US
dc.language.isoen_USen_US
dc.titleSynthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activitiesen_US
dc.typeArticleen_US
dc.identifier.doi10.1039/c3ob40624een_US
dc.identifier.journalORGANIC & BIOMOLECULAR CHEMISTRYen_US
dc.citation.volume11en_US
dc.citation.issue24en_US
dc.citation.spage3943en_US
dc.citation.epage3948en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000319670100002-
dc.citation.woscount8-
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