標題: | The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors |
作者: | Lin, Yu-Ling Lai, Wen-Lin Harn, Horng-jyh Hung, Pei-Hsiu Hsieh, Ming-Chang Chang, Kai-Fu Huang, Xiao-Fan Liao, Kuang-Wen Lee, Ming-Shih Tsai, Nu-Man 生物科技學院 生物資訊及系統生物研究所 分子醫學與生物工程研究所 College of Biological Science and Technology Institude of Bioinformatics and Systems Biology Institute of Molecular Medicine and Bioengineering |
公開日期: | 2013 |
摘要: | Glioblastoma multiforme (GBM) is a highly vascularized and invasive neoplasm. The methanol extract of Angelica sinensis (AS-M) is commonly used in traditional Chinese medicine to treat several diseases, such as gastric mucosal damage, hepatic injury, menopausal symptoms, and chronic glomerulonephritis. AS-M also displays potency in suppressing the growth of malignant brain tumor cells. The growth suppression of malignant brain tumor cells by AS-M results from cell cycle arrest and apoptosis. AS-M upregulates expression of cyclin kinase inhibitors, including p16, to decrease the phosphorylation of Rb proteins, resulting in arrest at the G(0)-G(1) phase. The expression of the p53 protein is increased by AS-M and correlates with activation of apoptosis-associated proteins. Therefore, the apoptosis of cancer cells induced by AS-M may be triggered through the p53 pathway. In in vivo studies, AS-M not only suppresses the growth of human malignant brain tumors but also significantly prolongs patient survival. In addition, AS-M has potent anticancer effects involving cell cycle arrest, apoptosis, and antiangiogenesis. The in vitro and in vivo anticancer effects of AS-M indicate that this extract warrants further investigation and potential development as a new antibrain tumor agent, providing new hope for the chemotherapy of malignant brain cancer. |
URI: | http://hdl.handle.net/11536/23177 http://dx.doi.org/10.1155/2013/394636 |
ISSN: | 1741-427X |
DOI: | 10.1155/2013/394636 |
期刊: | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE |
顯示於類別: | 期刊論文 |