Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, Yu-Ling | en_US |
dc.contributor.author | Lai, Wen-Lin | en_US |
dc.contributor.author | Harn, Horng-jyh | en_US |
dc.contributor.author | Hung, Pei-Hsiu | en_US |
dc.contributor.author | Hsieh, Ming-Chang | en_US |
dc.contributor.author | Chang, Kai-Fu | en_US |
dc.contributor.author | Huang, Xiao-Fan | en_US |
dc.contributor.author | Liao, Kuang-Wen | en_US |
dc.contributor.author | Lee, Ming-Shih | en_US |
dc.contributor.author | Tsai, Nu-Man | en_US |
dc.date.accessioned | 2014-12-08T15:33:18Z | - |
dc.date.available | 2014-12-08T15:33:18Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.issn | 1741-427X | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/23177 | - |
dc.identifier.uri | http://dx.doi.org/10.1155/2013/394636 | en_US |
dc.description.abstract | Glioblastoma multiforme (GBM) is a highly vascularized and invasive neoplasm. The methanol extract of Angelica sinensis (AS-M) is commonly used in traditional Chinese medicine to treat several diseases, such as gastric mucosal damage, hepatic injury, menopausal symptoms, and chronic glomerulonephritis. AS-M also displays potency in suppressing the growth of malignant brain tumor cells. The growth suppression of malignant brain tumor cells by AS-M results from cell cycle arrest and apoptosis. AS-M upregulates expression of cyclin kinase inhibitors, including p16, to decrease the phosphorylation of Rb proteins, resulting in arrest at the G(0)-G(1) phase. The expression of the p53 protein is increased by AS-M and correlates with activation of apoptosis-associated proteins. Therefore, the apoptosis of cancer cells induced by AS-M may be triggered through the p53 pathway. In in vivo studies, AS-M not only suppresses the growth of human malignant brain tumors but also significantly prolongs patient survival. In addition, AS-M has potent anticancer effects involving cell cycle arrest, apoptosis, and antiangiogenesis. The in vitro and in vivo anticancer effects of AS-M indicate that this extract warrants further investigation and potential development as a new antibrain tumor agent, providing new hope for the chemotherapy of malignant brain cancer. | en_US |
dc.language.iso | en_US | en_US |
dc.title | The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1155/2013/394636 | en_US |
dc.identifier.journal | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | en_US |
dc.contributor.department | 生物科技學院 | zh_TW |
dc.contributor.department | 生物資訊及系統生物研究所 | zh_TW |
dc.contributor.department | 分子醫學與生物工程研究所 | zh_TW |
dc.contributor.department | College of Biological Science and Technology | en_US |
dc.contributor.department | Institude of Bioinformatics and Systems Biology | en_US |
dc.contributor.department | Institute of Molecular Medicine and Bioengineering | en_US |
dc.identifier.wosnumber | WOS:000327264900001 | - |
dc.citation.woscount | 1 | - |
Appears in Collections: | Articles |
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