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dc.contributor.authorLin, Yu-Lingen_US
dc.contributor.authorLai, Wen-Linen_US
dc.contributor.authorHarn, Horng-jyhen_US
dc.contributor.authorHung, Pei-Hsiuen_US
dc.contributor.authorHsieh, Ming-Changen_US
dc.contributor.authorChang, Kai-Fuen_US
dc.contributor.authorHuang, Xiao-Fanen_US
dc.contributor.authorLiao, Kuang-Wenen_US
dc.contributor.authorLee, Ming-Shihen_US
dc.contributor.authorTsai, Nu-Manen_US
dc.date.accessioned2014-12-08T15:33:18Z-
dc.date.available2014-12-08T15:33:18Z-
dc.date.issued2013en_US
dc.identifier.issn1741-427Xen_US
dc.identifier.urihttp://hdl.handle.net/11536/23177-
dc.identifier.urihttp://dx.doi.org/10.1155/2013/394636en_US
dc.description.abstractGlioblastoma multiforme (GBM) is a highly vascularized and invasive neoplasm. The methanol extract of Angelica sinensis (AS-M) is commonly used in traditional Chinese medicine to treat several diseases, such as gastric mucosal damage, hepatic injury, menopausal symptoms, and chronic glomerulonephritis. AS-M also displays potency in suppressing the growth of malignant brain tumor cells. The growth suppression of malignant brain tumor cells by AS-M results from cell cycle arrest and apoptosis. AS-M upregulates expression of cyclin kinase inhibitors, including p16, to decrease the phosphorylation of Rb proteins, resulting in arrest at the G(0)-G(1) phase. The expression of the p53 protein is increased by AS-M and correlates with activation of apoptosis-associated proteins. Therefore, the apoptosis of cancer cells induced by AS-M may be triggered through the p53 pathway. In in vivo studies, AS-M not only suppresses the growth of human malignant brain tumors but also significantly prolongs patient survival. In addition, AS-M has potent anticancer effects involving cell cycle arrest, apoptosis, and antiangiogenesis. The in vitro and in vivo anticancer effects of AS-M indicate that this extract warrants further investigation and potential development as a new antibrain tumor agent, providing new hope for the chemotherapy of malignant brain cancer.en_US
dc.language.isoen_USen_US
dc.titleThe Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumorsen_US
dc.typeArticleen_US
dc.identifier.doi10.1155/2013/394636en_US
dc.identifier.journalEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINEen_US
dc.contributor.department生物科技學院zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentCollege of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000327264900001-
dc.citation.woscount1-
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