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dc.contributor.authorJean, Ren-Deren_US
dc.contributor.authorCheng, Wei-Daen_US
dc.contributor.authorHsiao, Meng-Hsuanen_US
dc.contributor.authorChou, Fu-Hsuanen_US
dc.contributor.authorBow, Jong-Shingen_US
dc.contributor.authorLiu, Dean-Moen_US
dc.date.accessioned2014-12-08T15:33:21Z-
dc.date.available2014-12-08T15:33:21Z-
dc.date.issued2014-02-15en_US
dc.identifier.issn0956-5663en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.bios.2013.08.047en_US
dc.identifier.urihttp://hdl.handle.net/11536/23187-
dc.description.abstractMetallic nanoparticles have been utilized as an analytical tool to detecting a wide variety of organic analytes. Among them, gold nanoparticles demonstrating outstanding surface plasmonic resonance property have been well recognized and received wide attention for plasmon-based sensing applications. However, in literature, gold-based nanosensor has to be integrated with specific "ligand" molecule in order to gain molecular recognition ability. However, "ligand" molecules, included proteins, peptides, nucleic acids, etc. are expensive and vulnerable to environmental change, in the meantime, anchoring procedure of the "ligand" molecules to gold surface may be cost-ineffective and endangered to the ligand's activity, making a final analytic probe less reliable and risk in production capability. Here, we develop a new approach by designing a colloid-type sensor using a few "bare" Au nanorods deposited on the surface of a colloidal chitosan carrier. By tuning the solution pH, the resulting colloidal nanoprobe is capable of detecting proteins, i.e., human serum albumin and lysozyme, with high specificity and sensitivity. This new approach allows a new type of the molecular probes to be well manipulated to monitor important biomolecules for medical detection, diagnosis, and bioengineering applications. (C) 2013 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectBiosensoren_US
dc.subjectElectrostatic interactionen_US
dc.subjectGold nanoroden_US
dc.subjectSelectivityen_US
dc.subjectHuman serum albuminen_US
dc.subjectLysozymeen_US
dc.titleHighly electrostatically-induced detection selectivity and sensitivity for a colloidal biosensor made of chitosan nanoparticle decorated with a few bare-surfaced gold nanorodsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bios.2013.08.047en_US
dc.identifier.journalBIOSENSORS & BIOELECTRONICSen_US
dc.citation.volume52en_US
dc.citation.issueen_US
dc.citation.spage111en_US
dc.citation.epage117en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000328095400017-
dc.citation.woscount2-
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