標題: | Total Synthesis of a Glycoglycerolipid from Meiothermus taiwanensis through a One-Pot Glycosylation Reaction and Exploration of its Immunological Properties |
作者: | Ghosh, Bhaswati Lai, Yen-Hsun Shih, Yu-Yin Pradhan, Tapan Kumar Lin, Chun-Hung Mong, Kwok-Kong Tony 應用化學系 Department of Applied Chemistry |
關鍵字: | glycosylation;immunology;lipids;natural products;total synthesis |
公開日期: | 1-十二月-2013 |
摘要: | The total synthesis of a glycoglycerolipid isolate of Meiothermus taiwanensis and its truncated structural analogues is reported. Our synthesis employed DMF-modulated and low-concentration glycosylation reactions for the construction of - and -glycosidic bonds in the absence of participating protecting groups. Further simplification of the synthesis was achieved by employing a low-concentration one-pot glycosylation procedure. Preliminary immunological studies showed that one of the truncated structural analogues suppressed the cytokine production of THP-1 monocytes. |
URI: | http://dx.doi.org/10.1002/asia.201300933 http://hdl.handle.net/11536/23229 |
ISSN: | 1861-4728 |
DOI: | 10.1002/asia.201300933 |
期刊: | CHEMISTRY-AN ASIAN JOURNAL |
Volume: | 8 |
Issue: | 12 |
起始頁: | 3191 |
結束頁: | 3199 |
顯示於類別: | 期刊論文 |