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dc.contributor.authorKuan, Tang-Chingen_US
dc.contributor.authorChen, Mu-Yuanen_US
dc.contributor.authorLiao, Yan-Chiouen_US
dc.contributor.authorKo, Lien_US
dc.contributor.authorHong, Yi-Hanen_US
dc.contributor.authorYen, Chun-Yien_US
dc.contributor.authorHsieh, Wen-Yehen_US
dc.contributor.authorCheng, Kun-Shanen_US
dc.contributor.authorWu, Chien-Liangen_US
dc.contributor.authorLin, Chih-Shengen_US
dc.date.accessioned2014-12-08T15:33:29Z-
dc.date.available2014-12-08T15:33:29Z-
dc.date.issued2013-12-01en_US
dc.identifier.issn0829-8211en_US
dc.identifier.urihttp://dx.doi.org/10.1139/bcb-2013-0031en_US
dc.identifier.urihttp://hdl.handle.net/11536/23238-
dc.description.abstractAngiotensin converting enzyme II (ACE2) is a component of the renin-angiotensin system (RAS) that negatively regulates angiotensin II (Ang II). Ang II, in turn, affects the expression of matrix metalloproteinases (MMPs) to induce heart remodeling. The specific mechanisms by which ACE2 regulates MMP-2, however, remain unclear. The aim of this study was to investigate the regulatory relationships between Ang II, ACE2, and MMP-2. ACE2 expression was upregulated and downregulated in human cardiofibroblasts (HCFs) by lentiviral infection. Effects on MMP-2 activity, shed ACE2 activity, extracellular signal-regulated kinase (ERK) signaling pathway, and ADAM metallopeptidase domain 17 (ADAM17) expression were assessed. ACE2 increased MMP-2 activity, and Ang II inhibited this effect through the Ang II type-1 receptor (AT1R) and ERK1/2 signaling pathway. Ang II also reduced the effect of ACE2 on ERK1/2 levels, the activity of shed ACE2, and adam17 expression in HCFs. Additionally, these Ang II-mediated reductions could be attenuated by AT1R antagonist valsartan. In conclusion, these data help to clarify how ACE2 and Ang II interact to regulate MMP-2 and control tissue remodeling in heart disease.en_US
dc.language.isoen_USen_US
dc.subjectangiotensin IIen_US
dc.subjectangiotensin-converting enzyme IIen_US
dc.subjectmatrix metalloproteinases-2en_US
dc.subjecthuman cardiofibroblastsen_US
dc.titleAngiotensin II downregulates ACE2-mediated enhancement of MMP-2 activity in human cardiofibroblastsen_US
dc.typeArticleen_US
dc.identifier.doi10.1139/bcb-2013-0031en_US
dc.identifier.journalBIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIREen_US
dc.citation.volume91en_US
dc.citation.issue6en_US
dc.citation.spage435en_US
dc.citation.epage442en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000327142700016-
dc.citation.woscount0-
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