標題: Ionic liquid supported multistep divergent synthesis of benzimidazole linked pyrrolo-/pyrido-/isoindolo-benzimidazolones
作者: Thummanagoti, Suman
Yellol, Gorakh S.
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Ionic liquid support;Microwave synthesis;Cascade reaction;Bis-heterocycles;Benzimidazoles
公開日期: 1-Jun-2011
摘要: Diversity oriented parallel synthesis for bis-heterocyclic skeletal novel benzimidazole linked pyrrolo-/pyrido-benzimidazolones and benzimidazole linked isoindolo-benzimidazolones has been developed on ionic liquid support under microwave irradiation by utilizing the cascade cyclization. The key tandem transformation comprises (i) amino-alkylation of immobilized o-phenylenediamine with ketoacids, (ii) intramolecular cyclization through secondary amine on electrophilic imine carbon toward pentacyclic aza-ring and (iii) second amido-cyclization to deliver cycloamide ring. The synergy arises by combined use of microwave heating with ionic liquid support which is very effectively used to speed up multistep synthesis of biological interesting heterocycles. (C) 2011 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.tetlet.2011.03.046
http://hdl.handle.net/11536/23289
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2011.03.046
期刊: TETRAHEDRON LETTERS
Volume: 52
Issue: 22
起始頁: 2818
結束頁: 2822
Appears in Collections:Articles


Files in This Item:

  1. 000291072300005.pdf

If it is a zip file, please download the file and unzip it, then open index.html in a browser to view the full text content.