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dc.contributor.authorChang, Chien-Jungen_US
dc.contributor.authorYang, Ten-Fangen_US
dc.contributor.authorLee, Tin-Ien_US
dc.contributor.authorChen, Yao-Changen_US
dc.contributor.authorKao, Yu-Hsunen_US
dc.contributor.authorChen, Shih-Annen_US
dc.contributor.authorChen, Yi-Jenen_US
dc.date.accessioned2014-12-08T15:34:36Z-
dc.date.available2014-12-08T15:34:36Z-
dc.date.issued2014-01-01en_US
dc.identifier.issn1011-6842en_US
dc.identifier.urihttp://hdl.handle.net/11536/23620-
dc.description.abstractBackground:The pulmonary veins (PVs) and atria are important foci during that period when atrial fibrillation (AF) is generated and maintained. It is well understood that hypertension and diabetes mellitus (DM) are important risk factors for AF. Dipeptidyl peptidase-IV (DPP-4) inhibitors are new agents in the fight against type 2 DM, though they have been found to have several cardiovascular effects. However, it is not clear whether DPP-4 may modulate the electrical and mechanical characteristics in hypertensive atrium or PVs. Methods: Conventional microelectrodes were used to record the action potentials (APs) in isolated PVs, right atrium (RA), and left atrium (LA) in Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) with or without sitagliptin (10 mg/kg) for 4 weeks. Results: WKY (n = 5), SHR (n =7), sitagliptin-treated WKY (n = 5) and sitagliptin-treated SHR (n = 7) had similar PV or sinoatrial spontaneous beating rates. However, the sitagliptin-treated WKY had fewer sinoatrial-PV beating rate differences than WKY, SHR or sitagliptin-treated SHR. WKY and SHR had shorter 90% (APD90) of RA AP duration than sitagliptin-treated WKY or sitagliptin-treated SHR. In contrast, WKY had longer LA APD90 than sitagliptintreated WKY, but SHR and sitagliptin-treated SHR had similar LA APD90. Sitagliptin-treated WKY or sitagliptintreated SHR had larger (RA-LA) APD90 differences than WKY or SHR, respectively. Moreover, as compared to WKY the post-rest potentiation of contraction was decreased in SHR, sitagliptin-treated WKY, and sitagliptin-treated SHR. Conclusions: Sitagliptin significantly affects the electromechanical characteristics of PVs and atria, which can be modulated by hypertension.en_US
dc.language.isoen_USen_US
dc.subjectAtrial fibrillationen_US
dc.subjectAtriumen_US
dc.subjectDipeptidyl peptidase inhibitor-4en_US
dc.subjectHypertensionen_US
dc.subjectPulmonary veinen_US
dc.titleSitagliptin Modulates the Electrical and Mechanical Characteristics of Pulmonary Vein and Atriumen_US
dc.typeArticleen_US
dc.identifier.journalACTA CARDIOLOGICA SINICAen_US
dc.citation.volume30en_US
dc.citation.issue1en_US
dc.citation.spage29en_US
dc.citation.epage37en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000330015400005-
dc.citation.woscount0-
Appears in Collections:Articles