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dc.contributor.authorChang, Chih-Yuen_US
dc.contributor.authorChen, Wen-Liangen_US
dc.contributor.authorLiou, Yi-Fanen_US
dc.contributor.authorKe, Chih-Chien_US
dc.contributor.authorLee, Hua-Chinen_US
dc.contributor.authorHuang, Hui-Lingen_US
dc.contributor.authorCiou, Li-Pingen_US
dc.contributor.authorChou, Chu-Chungen_US
dc.contributor.authorYang, Mei-Chuehen_US
dc.contributor.authorHo, Shinn-Yingen_US
dc.contributor.authorLin, Yan-Renen_US
dc.date.accessioned2014-12-08T15:35:25Z-
dc.date.available2014-12-08T15:35:25Z-
dc.date.issued2014-03-13en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0089867en_US
dc.identifier.urihttp://hdl.handle.net/11536/23980-
dc.description.abstractFemoral neck fracture is common in the elderly, and its impact has increased in aging societies. Comorbidities, poor levels of activity and pain may contribute to the development of depression, but these factors have not been well addressed. This study aims to investigate the frequency and risk of major depression after a femoral neck fracture using a nationwide population-based study. The Taiwan Longitudinal Health Insurance Database was used in this study. A total of 4,547 patients who were hospitalized for femoral neck fracture within 2003 to 2007 were recruited as a study group; 13,641 matched non-fracture participants were enrolled as a comparison group. Each patient was prospectively followed for 3 years to monitor the occurrence of major depression. Cox proportional-hazards models were used to compute the risk of major depression between members of the study and comparison group after adjusting for residence and sociodemographic characteristics. The most common physical comorbidities that were present after the fracture were also analyzed. The incidences of major depression were 1.2% (n = 55) and 0.7% (n = 95) in the study and comparison groups, respectively. The stratified Cox proportional analysis showed a covariate-adjusted hazard ratio of major depression among patients with femoral neck fracture that was 1.82 times greater (95% CI, 1.30-2.53) than that of the comparison group. Most major depressive episodes (34.5%) presented within the first 200 days following the fracture. In conclusion, patients with a femoral neck fracture are at an increased risk of subsequent major depression. Most importantly, major depressive episodes mainly occurred within the first 200 days following the fracture.en_US
dc.language.isoen_USen_US
dc.titleIncreased Risk of Major Depression in the Three Years following a Femoral Neck Fracture-A National Population-Based Follow-Up Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0089867en_US
dc.identifier.journalPLOS ONEen_US
dc.citation.volume9en_US
dc.citation.issue3en_US
dc.citation.epageen_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.department多媒體工程研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.contributor.departmentInstitute of Multimedia Engineeringen_US
dc.identifier.wosnumberWOS:000332851300010-
dc.citation.woscount0-
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