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dc.contributor.authorHuang, Keng-Shiangen_US
dc.contributor.authorYang, Chih-Huien_US
dc.contributor.authorKung, Chao-Pingen_US
dc.contributor.authorGrumezescu, Alexandru Mihaien_US
dc.contributor.authorKer, Ming-Douen_US
dc.contributor.authorLin, Yung-Shengen_US
dc.contributor.authorWang, Chih-Yuen_US
dc.date.accessioned2014-12-08T15:35:37Z-
dc.date.available2014-12-08T15:35:37Z-
dc.date.issued2014-02-01en_US
dc.identifier.issn0173-0835en_US
dc.identifier.urihttp://dx.doi.org/10.1002/elps.201300194en_US
dc.identifier.urihttp://hdl.handle.net/11536/24046-
dc.description.abstractA core-shell gelatin-alginate composite used for intestine-released oral delivery drug carrier was synthesized through microfluidic technique. At the fixed continuous phase flow rate, the size of the core-shell gelatin-alginate microparticles increases with the dispersed phase flow rate, and monodispersity can be retained (the variation coefficient for the diameter distribution can be kept less than 10%). The fabricated microparticles could remain intact in gastric juice for at least 3 h, indicating that the gelatin core could be well protected by alginate shell in acid environment. However, the alginate shell of the microparticles would swell or collapse in alkali environment in half an hour, assuring the controlled drug release in intestinal juice. The fabricated uniform core-shell gelatin-alginate microparticles were potential as pH-responsive drug carriers.en_US
dc.language.isoen_USen_US
dc.subjectAlginateen_US
dc.subjectGelatinen_US
dc.subjectIntestinal-releaseden_US
dc.subjectMicrofluidicen_US
dc.subjectOral delivery drug carrieren_US
dc.titleSynthesis of uniform core-shell gelatin-alginate microparticles as intestine-released oral delivery drug carrieren_US
dc.typeArticleen_US
dc.identifier.doi10.1002/elps.201300194en_US
dc.identifier.journalELECTROPHORESISen_US
dc.citation.volume35en_US
dc.citation.issue2-3en_US
dc.citation.spage330en_US
dc.citation.epage336en_US
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.identifier.wosnumberWOS:000331899400013-
dc.citation.woscount1-
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