Sequential one-pot enzymatic synthesis of oligo-N-acetyllactosamine and its multi-sialylated extensions

doi:10.1039/c4cc01227e

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DC 欄位	值	語言
dc.contributor.author	Chien, Wei-Ting	en_US
dc.contributor.author	Liang, Chien-Fu	en_US
dc.contributor.author	Yu, Ching-Ching	en_US
dc.contributor.author	Lin, Chien-Hung	en_US
dc.contributor.author	Li, Si-Peng	en_US
dc.contributor.author	Primadona, Indah	en_US
dc.contributor.author	Chen, Yu-Ju	en_US
dc.contributor.author	Mong, Kwok Kong T.	en_US
dc.contributor.author	Lin, Chun-Cheng	en_US
dc.date.accessioned	2014-12-08T15:35:56Z	-
dc.date.available	2014-12-08T15:35:56Z	-
dc.date.issued	2014	en_US
dc.identifier.issn	1359-7345	en_US
dc.identifier.uri	http://hdl.handle.net/11536/24312	-
dc.identifier.uri	http://dx.doi.org/10.1039/c4cc01227e	en_US
dc.description.abstract	A simple and efficient protocol for the preparative-scale synthesis of various lengths of oligo-N-acetyllactosamine (oligo-LacNAc) and its multi-sialylated extensions is described. The strategy utilizes one thermophilic bacterial thymidylyltransferase (RmlA) coupled with corresponding sugar-1-phosphate kinases to generate two uridine diphosphate sugars, UDP-galactose and UDP-N-acetylglucosamine. By incorporating glycosyltransferases, oligo-LacNAcs and their sialylated analogs were synthesized.	en_US
dc.language.iso	en_US	en_US
dc.title	Sequential one-pot enzymatic synthesis of oligo-N-acetyllactosamine and its multi-sialylated extensions	en_US
dc.type	Article	en_US
dc.identifier.doi	10.1039/c4cc01227e	en_US
dc.identifier.journal	CHEMICAL COMMUNICATIONS	en_US
dc.citation.volume	50	en_US
dc.citation.issue	43	en_US
dc.citation.spage	5786	en_US
dc.citation.epage	5789	en_US
dc.contributor.department	應用化學系	zh_TW
dc.contributor.department	Department of Applied Chemistry	en_US
dc.identifier.wosnumber	WOS:000335554300028	-
dc.citation.woscount	1	-
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