標題: | Through Diffusion Tensor Magnetic Resonance Imaging to Evaluate the Original Properties of Neural Pathways of Patients with Partial Seizures and Secondary Generalization by Individual Anatomic Reference Atlas |
作者: | Peng, Syu-Jyun Harnod, Tomor Tsai, Jang-Zern Huang, Chien-Chun Ker, Ming-Dou Chiou, Jun-Chern Chiueh, Herming Wu, Chung-Yu Hsin, Yue-Loong 生醫電子轉譯研究中心 Biomedical Electronics Translational Research Center |
公開日期: | 2014 |
摘要: | To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched normal subjects were imaged with high-resolution and diffusion tensor MRIs. Automated demarcation of supratentorial fibers was accomplished with personalized fiber-labeled atlases. From the individual atlases, we observed significant elevation of mean diffusivity (MD) in fornix (cres)/stria terminalis (FX/ST) and sagittal stratum (SS) and a significant difference in fractional anisotropy (FA) among FX/ST, SS, posterior limb of the internal capsule (PLIC), and posterior thalamic radiation (PTR). For patients with early-onset epilepsy, the diffusivities of the SS and the retrolenticular part of the internal capsule were significantly elevated, and the anisotropies of the FX/ST and SS were significantly decreased. In the drug-resistant subgroup, the MDs of SS and PTR and the FAs of SS and PLIC were significantly different. Onset age was positively correlated with increases in FAs of the genu of the corpus callosum. Patients with neocortical seizures and secondary generalisation had microstructural anomalies in WM. The changes in WM are relevant to early onset, progression, and severity of epilepsy. |
URI: | http://hdl.handle.net/11536/24518 http://dx.doi.org/10.1155/2014/419376 |
ISSN: | 2314-6133 |
DOI: | 10.1155/2014/419376 |
期刊: | BIOMED RESEARCH INTERNATIONAL |
顯示於類別: | 期刊論文 |