標題: | Oligonucleotides as \'bio-solvent\' for in situ extraction and functionalisation of carbon nanoparticles |
作者: | Chen, Yu-Cheng Wen, Cheng-Che Liau, Ian Hsieh, You-Zung Hsu, Hsin-Yun 應用化學系 應用化學系分子科學碩博班 Department of Applied Chemistry Institute of Molecular science |
公開日期: | 1-一月-2014 |
摘要: | A simple yet novel one-pot approach is developed to prepare carbon nanoparticles with diameters of similar to 2 nm and modified by oligonucleotides. We use single-stranded deoxyribonucleic acid (ssDNA), which serves as a unique \'bio-solvent\' for carbon nanoparticle (CNP) preparation and as a target molecule for functionalisation. Proposed interactions relevant to the stabilisation of the final oligonucleotide-CNP complex include pi-pi stacking and pi-HN bonding with sp(2) carbon atoms on the CNP surface. Furthermore, oligonucleotide-enriched CNPs can be readily extracted within seconds from a crude mixture of single-walled carbon nanotubes (SWCNTs) without any need for post-synthesis chemical modification. The established CNPs are biocompatible, possess intrinsic fluorescence, and do not result in the undesirable photobleaching effect, rendering them potential candidates for in vivo biological applications. |
URI: | http://dx.doi.org/10.1039/c4tb00314d http://hdl.handle.net/11536/24583 |
ISSN: | 2050-750X |
DOI: | 10.1039/c4tb00314d |
期刊: | JOURNAL OF MATERIALS CHEMISTRY B |
Volume: | 2 |
Issue: | 26 |
起始頁: | 4100 |
結束頁: | 4107 |
顯示於類別: | 期刊論文 |