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dc.contributor.authorHuang, Wei-Chenen_US
dc.contributor.authorLiu, Kun-Hoen_US
dc.contributor.authorLiu, Ta-Chungen_US
dc.contributor.authorLiu, Dean-Moen_US
dc.contributor.authorChen, San-Yuanen_US
dc.date.accessioned2014-12-08T15:36:31Z-
dc.date.available2014-12-08T15:36:31Z-
dc.date.issued2014-08-01en_US
dc.identifier.issn1742-7061en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.actbio.2014.04.025en_US
dc.identifier.urihttp://hdl.handle.net/11536/24853-
dc.description.abstractIn this study, a new type of polydimethylsiloxane-modified chitosan (PMSC) amphiphilic hydrogel was developed as a soft substrate to explore cellular responses for dermal reconstruction. The hydrogel wettability, mechanical stiffness and topography were controllable through manipulation of the degree of esterification (DE) between hydrophobic polydimethylsiloxane (PDMS) and hydrophilic N,O-(carboxymethyl)-chitosan (NOCC). Based on microphase separation, the incorporation of PDMS into NOCC increased the stiffness of the hybrid through the formation of self-assembled aggregates, which also provided anchor sites for cell adhesion. As the DE exceeded 0.39, the size of the PDMS-rich aggregates changed from nanoscale to microscale. Subsequently, the hierarchical architecture resulted in an increase in the tensile modulus of the hybrid gel up to fourfold, which simultaneously provided mechano-topographic guidance and allowed the cells to completely spread to form spindle shapes instead of forming a spherical morphology, as on NOCC (DE = 0). The results revealed that the incorporation of hydrophobic PDMS not only impeded acidic damage resulting from NOCC but also acted as an adhesion modification agent to facilitate long-term cell adhesion and proliferation on the soft substrate. As proved by the promotion on long-term type-I collagen production, the PMSC hybrid with self-assembled mechano-topography offers great promise as an advanced scaffold material for use in healing applications. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectAmphiphilic copolymeren_US
dc.subjectCell adhesionen_US
dc.subjectInterface manipulationen_US
dc.subjectMechanical stiffnessen_US
dc.subjectTopographyen_US
dc.titleSynergistic hierarchical silicone-modified polysaccharide hybrid as a soft scaffold to control cell adhesion and proliferationen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.actbio.2014.04.025en_US
dc.identifier.journalACTA BIOMATERIALIAen_US
dc.citation.volume10en_US
dc.citation.issue8en_US
dc.citation.spage3546en_US
dc.citation.epage3556en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000339459500017-
dc.citation.woscount1-
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