標題: Photoresponsive Protein-Graphene-Protein Hybrid Capsules with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy
作者: Hu, Shang-Hsiu
Fang, Ren-Hong
Chen, Yu-Wei
Liao, Bang-Jie
Chen, I-Wei
Chen, San-Yuan
材料科學與工程學系
Department of Materials Science and Engineering
公開日期: 1-七月-2014
摘要: A novel photo-responsive protein-graphene-protein (PGP) capsule that doubles as a photothermal agent with core/shell structure is constructed by anchoring reduced graphene oxide nanosheets on one-component protein (lactoferrin) shell through a double emulsion method. PGP capsules can transport fully concealed hydrophilic anticancer cargo, doxorubicin (Dox), with a large payload (9.43 mu mol g(-1)) to be later unloaded in a burst-like manner by photo-actuation triggered by near-infrared irradiation. Being bio-compatible yet with a high cancer cell targeting efficiency, PGP capsules have successfully eradicated subcutaneous tumors in 10 d following a single 5 min NIR irradiation without distal damage. Besides, the photochemothermal therapy of PGP capsules eradicates tumor cells not only in the light-treating area but also widely light-omitted tumor cells, overcoming the tumor recurrence due to efficient cell killing efficacy. These results demonstrate that the PGP capsule is a potential new drug delivery platform for local-targeting, on-demand, photoresponsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications.
URI: http://dx.doi.org/10.1002/adfm.201400080
http://hdl.handle.net/11536/24893
ISSN: 1616-301X
DOI: 10.1002/adfm.201400080
期刊: ADVANCED FUNCTIONAL MATERIALS
Volume: 24
Issue: 26
起始頁: 4144
結束頁: 4155
顯示於類別:期刊論文


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