標題: | Photoresponsive Protein-Graphene-Protein Hybrid Capsules with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy |
作者: | Hu, Shang-Hsiu Fang, Ren-Hong Chen, Yu-Wei Liao, Bang-Jie Chen, I-Wei Chen, San-Yuan 材料科學與工程學系 Department of Materials Science and Engineering |
公開日期: | 1-七月-2014 |
摘要: | A novel photo-responsive protein-graphene-protein (PGP) capsule that doubles as a photothermal agent with core/shell structure is constructed by anchoring reduced graphene oxide nanosheets on one-component protein (lactoferrin) shell through a double emulsion method. PGP capsules can transport fully concealed hydrophilic anticancer cargo, doxorubicin (Dox), with a large payload (9.43 mu mol g(-1)) to be later unloaded in a burst-like manner by photo-actuation triggered by near-infrared irradiation. Being bio-compatible yet with a high cancer cell targeting efficiency, PGP capsules have successfully eradicated subcutaneous tumors in 10 d following a single 5 min NIR irradiation without distal damage. Besides, the photochemothermal therapy of PGP capsules eradicates tumor cells not only in the light-treating area but also widely light-omitted tumor cells, overcoming the tumor recurrence due to efficient cell killing efficacy. These results demonstrate that the PGP capsule is a potential new drug delivery platform for local-targeting, on-demand, photoresponsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications. |
URI: | http://dx.doi.org/10.1002/adfm.201400080 http://hdl.handle.net/11536/24893 |
ISSN: | 1616-301X |
DOI: | 10.1002/adfm.201400080 |
期刊: | ADVANCED FUNCTIONAL MATERIALS |
Volume: | 24 |
Issue: | 26 |
起始頁: | 4144 |
結束頁: | 4155 |
顯示於類別: | 期刊論文 |