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dc.contributor.authorKo, Fu-Hsiangen_US
dc.contributor.authorChang, Yu-Chengen_US
dc.date.accessioned2014-12-08T15:36:38Z-
dc.date.available2014-12-08T15:36:38Z-
dc.date.issued2014-01-01en_US
dc.identifier.issn2046-2069en_US
dc.identifier.urihttp://dx.doi.org/10.1039/c4ra02762ken_US
dc.identifier.urihttp://hdl.handle.net/11536/24981-
dc.description.abstractThe present study synthesizes different sizes of Au nanoparticles (NPs) by adjusting the concentration of citrate. This method produces Au NPs with uniform sizes that can be used to grow Au-Ag core-shell NPs by the seeding growth method. We report the fabrication of monolayer Au NPs or Au-Ag core-shell NPs through the self-assembly of NPs on a 3-aminopropyltrimethoxysilane (APTMS)-modified silicon substrate. The results indicate that the self-assembly time of Au NPs or Au-Ag core-shell NPs plays a crucial role in determining the surface coverage of NPs on the silicon substrate. The appropriate sizes of Au NPs or Au-Ag core-shell NPs were optimized to yield the greatest SERS effect in the rhodamine B molecule. The substrates with self-assembled Au-Ag core-shell NPs can also be used to detect adenosine by a structure-switch aptamer. The combination of Au-Ag core-shell NPs and DNA-based adenosine sensors provides a facile, high enhancement, low detection limit (0.1 nM) and low cost fabrication, which shall be of significant value for practical applications of other aptamer sensing systems.en_US
dc.language.isoen_USen_US
dc.titleAptamer based surface enhanced Raman scattering detection of adenosine using various core sizes of Au-Ag core-shell nanoparticlesen_US
dc.typeArticleen_US
dc.identifier.doi10.1039/c4ra02762ken_US
dc.identifier.journalRSC ADVANCESen_US
dc.citation.volume4en_US
dc.citation.issue50en_US
dc.citation.spage26251en_US
dc.citation.epage26257en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
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