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dc.contributor.authorHuang, GSen_US
dc.contributor.authorHong, MYen_US
dc.date.accessioned2014-12-08T15:36:43Z-
dc.date.available2014-12-08T15:36:43Z-
dc.date.issued2005en_US
dc.identifier.issn0192-415Xen_US
dc.identifier.urihttp://hdl.handle.net/11536/25076-
dc.identifier.urihttp://dx.doi.org/10.1142/S0192415X05003065en_US
dc.description.abstractDamp obstruction refers to the stagnation of vital energy (qi) caused by dampness resulting in dysfunction of body and limbs movement, as well as impairment of spleen and stomach digestive function. Damp obstruction is the dampness-induced imbalance of five elements; thus it serves as an ideal model for genomic study using cDNA microarray. We have performed microarray analyses to major organs of damp-obstructed rats. Cluster analysis for the expression profiles of major organs indicated that spleen, stomach, and kidney respond to dampness differently from heart, liver, lung, and brain. Gene expression profile specific to each element or group of elements was also identified. Our results are consistent with the philosophy of Chinese medicine that the five elements, metal (lung), wood (liver), water (kidney), fire (heart), and earth (spleen and stomach) coordinate by subjugation or restriction to maintain a healthy, physiological state. This is the first time that a powerful genomic tool was applied to probe the ancient theory of Chinese medicine.en_US
dc.language.isoen_USen_US
dc.subjectdamp obstructionen_US
dc.subjectmicroarrayen_US
dc.subjectelementsen_US
dc.subjectgene expressionen_US
dc.titleGenomic expression for rat model of damp obstruction in Chinese medicine: Application of microarray technologyen_US
dc.typeArticleen_US
dc.identifier.doi10.1142/S0192415X05003065en_US
dc.identifier.journalAMERICAN JOURNAL OF CHINESE MEDICINEen_US
dc.citation.volume33en_US
dc.citation.issue3en_US
dc.citation.spage459en_US
dc.citation.epage474en_US
dc.contributor.department材料科學與工程學系奈米科技碩博班zh_TW
dc.contributor.departmentGraduate Program of Nanotechnology , Department of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000230633800011-
dc.citation.woscount4-
Appears in Collections:Articles