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dc.contributor.authorChang, SLen_US
dc.contributor.authorChang, CLTen_US
dc.contributor.authorChiang, YMen_US
dc.contributor.authorHsieh, RHen_US
dc.contributor.authorTzeng, CRen_US
dc.contributor.authorWu, TKen_US
dc.contributor.authorSytwu, HKen_US
dc.contributor.authorShyur, LFen_US
dc.contributor.authorYang, WCen_US
dc.date.accessioned2019-04-03T06:37:55Z-
dc.date.available2019-04-03T06:37:55Z-
dc.date.issued2004-11-01en_US
dc.identifier.issn0032-0943en_US
dc.identifier.urihttp://dx.doi.org/10.1055/s-2004-832645en_US
dc.identifier.urihttp://hdl.handle.net/11536/25667-
dc.description.abstract\Compelling evidence suggests that infiltrating CD4(+) type I helper T (Th1) cells in the pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic (NOD) mice. We demonstrate in the present report that a butanol fraction of B. pilosa suppressed the development of diabetes, helped maintain levels of blood sugar and insulin in NOD mice in a dose-dependent manner and elevated the serum IgE levels regulated by Th2 cytokines in NOD mice. Moreover, the butanol fraction inhibited the differentiation of naive helper T (Th0) cells into Th1 cells but enhanced their transition into type II helper T (Th2) cells using an in vitro T cell differentiation assay. Two polyacetylenic compounds, 2-beta-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne and 3-beta-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne, identified from the butanol fraction also prevented the onset of diabetes like the butanol fraction. The latter compound showed a stronger activity for T cell differentiation than the former. In summary, the butanol fraction of B. pilosa and its polyacetylenes can prevent diabetes plausibly via suppressing the differentiation of Th0 cells into Th1 cells and promoting that of Th0 cells into Th2 cells.en_US
dc.language.isoen_USen_US
dc.subjectT helper cellsen_US
dc.subjectDifferentiationen_US
dc.subjectnon-obese diabetesen_US
dc.subjectautoimmunem diseasesen_US
dc.subjectBidens pilosaen_US
dc.subjectAsteraceaeen_US
dc.titlePolyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic miceen_US
dc.typeArticleen_US
dc.identifier.doi10.1055/s-2004-832645en_US
dc.identifier.journalPLANTA MEDICAen_US
dc.citation.volume70en_US
dc.citation.issue11en_US
dc.citation.spage1045en_US
dc.citation.epage1051en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000225506000007en_US
dc.citation.woscount47en_US
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