Multifunctional magnetically removable nanogated lids of Fe(3)O(4)-capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging

Abstract

In this study, a novel nanocarrier (MSN@Fe(3)O(4)) is constructed using a facile technology by capping mesoporous silica nanoparticles (MSN) with monodispersed Fe(3)O(4) nanoparticles through chemical bonding. The chemical links provide adhesion, which permits the magnetic nanoparticles, as nano-caps, to efficiently cover the mesoporous pores on the mesoporous silica matrix and be tightly bonded with the matrix surface. Without magnetic stimulus, none or only a negligible amount of the drug can be released from the MSN@Fe(3)O(4). However, when subjected to an external controllable magnetic field, a quantity of nano-caps can be remotely and precisely removed, giving tunable release profiles for an anticancer drug, (S)-(+)-camptothecin (CPT), with various dosages depending upon the strength and time period of magnetic induction. The transverse relaxivity (r(2)) of the MSN@Fe(3)O(4) nanocarriers was measured to be about 121.57 s(-1)mM(-1) Fe, which is larger than that for the reported mesoporous silica nanoparticles decorated with magnetite nanocrystals. Therefore, MSN@Fe(3)O(4) nanocarriers could perform well as T(2)-type MR contrast enhancement agents for cell or molecular imaging. In addition, the MSN@Fe(3)O(4) nanocarriers also demonstrate fairly high cell uptake efficiency. Together with its versatile magnetic manipulation, this new type of MSN@Fe(3)O(4) nanosystem can be considered as a new class of multifunctional nanodevice, with combined tunable drug release and nanoimaging modalities for a variety of biomedical uses.