標題: Novel approach towards the synthesis of skeletally diverse benzimidazole-pyrrolo[1,2-a]quinoxaline by S(N)Ar/Pictet-Spengler reaction under focused microwave irradiation
作者: Maiti, Barnali
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 1-一月-2011
摘要: In a study aimed at developing a novel concise approach to the benzimidazole-pyrrolo-[1,2-a]quinoxaline core of medicinal interest, a Pictet-Spengler reaction has been identified that gives direct access to the target compound on soluble polymer support under focused microwave irradiation. The pyrrole moiety has been introduced on polymer immobilized benzimidazole derivatives by S(N)Ar diversification which subsequently transformed to the title compounds via reduction followed by Pictet-Spengler cyclisation with various ketones in good yields and excellent purity. The work described here demonstrates the versatility of the base mediated SNAr reaction coupled with Pictet-Spengler cyclisation in the construction of novel heterocycles.
URI: http://dx.doi.org/10.1039/c1nj20153k
http://hdl.handle.net/11536/26155
ISSN: 1144-0546
DOI: 10.1039/c1nj20153k
期刊: NEW JOURNAL OF CHEMISTRY
Volume: 35
Issue: 7
起始頁: 1385
結束頁: 1396
顯示於類別:期刊論文