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dc.contributor.authorLin, Yu-Lingen_US
dc.contributor.authorChen, Yen-Shunen_US
dc.contributor.authorHsieh, Jui-Hungen_US
dc.contributor.authorLin, Ching-Minen_US
dc.contributor.authorWu, Hsin-Yien_US
dc.contributor.authorLin, Chen-Sien_US
dc.contributor.authorChu, Rea-Minen_US
dc.contributor.authorLiao, Kuang-Wenen_US
dc.contributor.authorHsu, Yuan-Hsunen_US
dc.date.accessioned2014-12-08T15:38:24Z-
dc.date.available2014-12-08T15:38:24Z-
dc.date.issued2010-12-01en_US
dc.identifier.issn1480-9222en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s12575-010-9033-9en_US
dc.identifier.urihttp://hdl.handle.net/11536/26285-
dc.description.abstractNF-kappa B regulates several important expressions, such as cytokine release, anti-apoptosis, adhesion molecule expression, and cell cycle processing. Several NF-kappa B inhibitors have been discovered as an anti-tumor or anti-inflammatory drug. The activity of NF-kappa B transcription factor is negatively regulated by I kappa B binding. In this study, I kappa B assay system was established and I kappa B-EGFP fusion protein was used as an indicator to monitor the effects of substances on the I kappa B degradation. The results indicated that the chosen hydroquinone could inhibit the I kappa B degradation and cause the cell de-attachment from the bottom of culture plate. In addition, this system could also monitor the I kappa B degradation of microbial metabolite of natural mixtures of propolis. Thus, the I kappa B assay system may be a good system for drug discovery related to microbial metabolite.en_US
dc.language.isoen_USen_US
dc.subjectMicrobial metaboliteen_US
dc.subjectAntioxidanten_US
dc.subjectI kappa Ben_US
dc.subjectEGFPen_US
dc.subjectHydroquinoneen_US
dc.subjectPropolisen_US
dc.titleUtilization of I kappa B-EGFP Chimeric Gene as an Indicator to Identify Microbial Metabolites with NF-kappa B Inhibitor Activityen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s12575-010-9033-9en_US
dc.identifier.journalBIOLOGICAL PROCEDURES ONLINEen_US
dc.citation.volume12en_US
dc.citation.issue1en_US
dc.citation.spage131en_US
dc.citation.epage138en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.identifier.wosnumberWOS:000284155300011-
dc.citation.woscount0-
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